![Adipogen/Delanzomib [CEP-18770]/AG-CR1-3673-M001/1 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3673.png)
Adipogen/Delanzomib [CEP-18770]/AG-CR1-3673-M001/1 mg
商品编号：
AG-CR1-3673-M001
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NPH007098;CT47098;CIP18770;[(1R)-1-[[(2S,3R)-3-Hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C21H28BN3O5 |
| MW | 413.3 |
| CAS | 847499-27-8 |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(20mg/ml)orethanol(20mg/ml).Slightlysolubleinchloroformormethanol.Poorlysolubleinwater(<1mg l).=""> |
| OtherProductData | Note:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice.Stocksolutionsarestableforatleast1monthwhenstoredat-20°C. |
| InChiKey | SJFBTAPEPRWNKH-CCKFTAQKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,selective,reversIBLeorallybioavailableproteasomeinhibitor.SyntheticP2threonineboronicacid.
- Targetsthechymotrypsin-likeβ5subunitoftheconstitutive20Sproteasome(IC50=3.8nM).Cross-reactsandinhibitsthecaspase-like/peptidyl-glutamylpeptide-hydrolyzing(PGPH)β1subunit(IC50=~70nM).
- Displayssimilarpotencyforthechymotrypsin-likeactivityoftheproteasomecomparedtobortezomib.Exhibitsafavorablecytotoxicityprofiletowardnormalhumanepithelialcells,bonemarrowProgenitorsandbonemarrow-derivedstromalcellsrelativetobortezomib(Prod.No.AG-CR1-3602).
- Anticancercompoundeffectiveagainstmultiplemyelomainvivo.
- Invitro,blocksthegrowthofrepresentativehumansolidandhematologicaltumorcelllines(IC50s=5.6-34nM).
- Showntodown-modulateNF-κB,induceapoptosis,inhibitangiogenesisandM-CSF-RANKL-inducedosteoclastogenesis.
ProductReferences
- DiscoveryofaPotent,Selective,andOrallyActiveProteasomeInhibitorfortheTreatmentofCancer:B.D.Dorsey,etal.;J.Med.Chem.51,1068(2008)
- CEP-18770:Anovel,orallyactiveproteasomeinhibitorwithatumor-selectivepharmacologicprofilecompetitivewithbortezomib:R.Piva,etal.;Blood111,2765(2008)
- TheproteasomeinhibitorCEP-18770enhancestheanti-myelomaactivityofbortezomibandmelphalan:E.Sanchez,etal.;Br.J.Haematol.148,569(2010)
- Novel,orallyactive,proteasomeinhibitor,delanzomib(CEP-18770),amelioratesdiseasesymptomsandglomerulonephritisintwopreclinicalmousemodelsofSLE:M.M.Seavey,etal.;Int.Immunopharmacol.12,257(2012)
- Probingthespecificityandactivityprofilesoftheproteasomeinhibitorsbortezomibanddelanzomib:C.R.Berkers,etal.;Mol.Pharm.9,1126(2012)
- Molecularmechanismsofacquiredproteasomeinhibitorresistance:A.J.Kale&B.S.Moore;J.Med.Chem.55,10317(2012)
- AfirstinhumanphaseIstudyoftheproteasomeinhibitorCEP-18770inpatientswithadvancedsolidtumoursandmultiplemyeloma:E.Gallerani,etal.;Eur.J.Cancer49,290(2013)
- Proteasomeinhibitorsinthetreatmentofmultiplemyeloma:A.McBride&P.Y.Ryan;ExpertRev.AnticancerTher.13,339(2013)(Review)
- PhaseI/IIstudyofthenovelproteasomeinhibitordelanzomib(CEP-18770)forrelapsedandrefractorymultiplemyeloma:D.T.Vogl,etal.;Leuk.Lymphoma58,1872(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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