Adipogen/Dasatinib/SYN-1036-M005/5 mg
商品编号：
SYN-1036-M005
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BMS-354825;Sprycel |
| ProductType | Chemical |
| Properties | |
| Formula | C22H26ClN7O2S |
| MW | 488.0 |
| CAS | 302962-49-8 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:Abl-BCR-BTK|KinaseGroup:PTK|Substrate:Tyrosine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | ZBNZXTGUTAYRHI-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TheBCR-ABLoncogenetriggersintracellularsignaling,activatingmultipletransductioncascades,promotingthegrowth,proliferationandsurvivalofhematopoieticcells.BCR-ABLplaysaroleindefectiveDNArepair,alterationofcellularadhesionandinhibitionofapoptosis.DegregulatedBCR-ABLtyrosinekinaseactivityisthemolecularMarkerforCML.InhibitingBCR-ABLtyrosinekinaseactivityleadstotheinductionofapoptosisandinhibitscellularproliferationinvitroandtherearevariousBCR-ABLisoformswithdifferingactivitylevelsaswell.Dasatinib(BMS-354825,Sprycel®)isapotentmulti-targetkinaseinhibitorofBCR-ABL.DasatiinibperformsbetteragainstABLkinasethanearlierdrugssuchasimatinib,andDasatinibalsoiseffectiveagainstSRCfamilyofkinases,andotherreceptorkinasessuchasEPHA2,PDGFR,andc-Kit.Dasatinib"sinhibitingpotentialagainstSrcfamilykinasemembersisgreater(IC(50)0.5nM)thanitsinhibitoryactivityagainstABL(1nM).
ProductReferences
- 2-aminothiazoleasanovelkinaseinhibitortemplate.Structure-activityrelationshipstudiestowardthediscoveryofN-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide(dasatinib,BMS-354825)asapotentpan-Srckinaseinhibitor:J.Das,etal.;J.Med.Chem.49,6819(2006)
- Dasatinibinchronicmyeloidleukemia:areview:D.G.Aguilera&A.M.Tsimberidou;Ther.Clin.Risk.Manag.5,281(2009)
- IdentificationofGZD824asanorallybioavailableinhibitorthattargetsphosphorylatedandnonphosphorylatedbreakpointclusterregion-Abelson(Bcr-Abl)kinaseandovercomesclinicallyacquiredmutation-inducedresistanceagainstimatinib:X.Ren,etal.;J.Med.Chem.56,879(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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