Adipogen/DAPT/AG-CR1-0016-M025/25 mg
商品编号：
AG-CR1-0016-M025
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycinetert.butylester |
| ProductType | Chemical |
| Properties | |
| Formula | C23H26F2N2O4 |
| MW | 432.5 |
| CAS | 208255-80-5 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solublein100%ethanol,DMSO(20mg/ml)ordichloromethane. |
| OtherProductData | Stocksolutionsarestableforupto3monthswhenstoredat-20°C. |
| InChiKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeableγ-secretaseinhibitor(IC50=115nMfortotalβ-amyloid,IC50=200nMforβ-amyloid1-42)[1].
- ReducesAβlevelsinvivo[2].
- Blockstheproteolyticprocessingofneurotrophinreceptoralikedeathdomainprotein(NRADD)[3].
- Doesnotinhibitpersenilinase[4].
- Notchprocessinginhibitor[5].
- Enhancesneuronaldifferentiationindependentofsonichedgehog(Shh)signaling[6].
- CDK5activityinhibitor[7].
- Apoptosisenhancer[8].
ProductReferences
- Functionalgamma-secretaseinhibitorsreducebeta-amyloidpeptidelevelsinbrain:H.F.Dovey,etal.;J.NeuRochem.76,173(2001)
- Thegamma-secretaseinhibitorN-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycinet-butylesterreducesAbetalevelsinvivoinplasmaandcerebrospinalfluidinyoung(plaque-free)andaged(plaque-bearing)Tg2576mice:T.A.Lanz,etal.;J.Pharmacol.Exp.Ther.305,864(2003)
- Releaseofamembrane-bounddeathdomainbygamma-secretaseprocessingofthep75NTRhomologNRADD:K.Gowrishankar,etal.;J.Cell.Sci.117,4099(2004)
- Presenilinendoproteolysismediatedbyanaspartylproteaseactivitypharmacologicallydistinctfromgamma-secretase:W.A.Campbell,etal.;J.Neurochem.85,1563(2003)
- Agamma-secretaseinhibitorblocksNotchsignalinginvivoandcausesasevereneurogenicphenotypeinzebrafish:A.Geling,etal.;EMBORep.3,688(2002)
- ThenotchresponseinhibitorDAPTenhancesneuronaldifferentiationinembryonicstemcell-derivedembryoidbodiesindependentlyofsonichedgehogsignaling:T.Q.Crawford&H.Roelink;Dev.Dyn.236,886(2007)
- TheNotchsignalinginhibitorDAPTdown-regulatescdk5activityandmodulatesthedistributionofneuronalcytoskeletalproteins:J.Kanungo,etal.;J.Neurochem.106,2236(2008)
- DAPTenhancestheapoptosisofhumantonguecarcinomacells:B.E.Grottklau,etal.;Int.J.OralSci.1,81(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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