Adipogen/Cytochalasin B/AG-CN2-0504-M005/5 mg
商品编号：
AG-CN2-0504-M005
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Phomin;NSC107658 |
| ProductType | Chemical |
| Properties | |
| Formula | C29H37NO5 |
| MW | 479.6 |
| CAS | 14930-96-2 |
| RTECS | RO0205000 |
| Source/HostChemicals | IsolatedfromPhomasp. |
| PurityChemicals | ≥97%(NMR) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,methanol,ethanolorDMF. |
| Identity | Determinedby1H-NMRandMS. |
| InChiKey | GBOGMAARMMDZGR-TYHYBEHESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeablemycotoxin.
- Actinpolymerizationinhibitor.Bindstothebarbedendofactin,reversIBLyinhibitingtheelongationandshorteningofactinfilaments.Inducesnuclearextrusion.
- Bydisruptingactinpolymerization,blocksdiversecellularfunctions,includingcelldivision,migration,phagocytosis,exocytosisandchemotaxis.InducesDNAfragmentation.
- Usedincytoskeletalreorganization,cellimagingandorganelletraffickingstudies.
- Potentantitumoractivity.Causescellcyclearrestandinducesapoptosisincancercells.Showntohaveaninhibitoryeffectontumorcellgrowthwithoutcausingimmunosuppressiveeffects.
- Non-competitiveglucosetransportinhibitor.InhibitsofGLUT1/GLUT2mediatedmonosaccharidetransportacrosstheplasmamembrane.DoesnotinhibitGLUT5.
- Usedfortestingthegenotoxicityofsubstancesinthecytokinesis-blockmicronucleuscytome(CBMNcyt)assay.
- Usedincloningthroughnucleartransfer.EnucleatedrecipientcellsaretreatedwithcytochalasinB.CytochalasinBmakesthecytoplasmoftheoocytesmorefluidandmakesitpossibletoaspiratethenucleargenomeoftheoocytewithinasmallvesicleofplasmamembraneintoamicro-needle.
- DecreasestheexpressionlevelsofDNMT1,DNMT3a,DNMT3b,HAT1andHDAC1atthepronuclearstageinporcineembryos.
- Phosphatidylcholineandphosphatidylethanolaminebiosynthesisinhibitor.
- Plateletaggregationinhibitor.
ProductReferences
- CytochalasinB.3.Inhibitionofhumanpolymorphonuclearleukocytephagocytosis:A.T.Davis,etal.;Proc.Soc.Exp.Biol.Med.137,161(1971)
- CytochalasinB:Inhibitionofglucoseandglucosaminetransport:R.D.Estensen&P.G.W.Plagemann;PNAS69,1430(1972)
- EnucleationofmammaliancellswithcytochalasinB:D.M.Prescott,etal.;Exp.CellRes.71,480(1972)
- InhibitionandreversalofplateletactivationbycytochalasinBorcolcemid:M.M.BoyleKay&H.H.Fudenberg;Nature244,288(1973)
- CytochalasinB:inhibitionofglucose-inducedinsulinreleasefromisolatedratpancreaticislets:P.Schauders&H.Frerichs;Diabetologia10,85(1974)
- ReversibleinhibitionofthemotilityofhumanspermatozoabycytochalasinB:R.N.Peterson&M.Freund;Fertil.Steril.28,257(1977)
- EffectsofcytochalasinBonendocytosisandexocytosis:P.Davies&A.C.Allison;Front.Biol.46,143(1978)
- MechanismofactionofcytochalasinBonactin:S:MacLean-Fletcher&T.D.Pollard;Cell.20,329(1980)
- EffectofcytochalasinBonglucoseuptake,utilization,oxidationandinsulinotropicactionintumoralinsulin-producingcells:W.J.Malaisse;Cell.Biochem.Funct. 5,183(1987)
- CytochalasinBinducescellularDNAfragmentation:M.A.Kolber,etal.;FASEBJ.4,3021(1990)
- InhibitionofPhosphatidylcholineandPhosphatidylethanoamineBiosynthesisbyCytochalasinBinCulturedGliomaCells:PotentialRegulationofBiosynthesisbyCa2+-DependentMechanisms:T.P.George,etal.;Biochim.Biophys.Acta1084,185(1991)
- CytochalasinBmayshortenactinfilamentsbyamechanismindependentofbarbedendcapping:P.A.Theodoropoulos,etal.;Biochem.Pharmacol.47,1875(1994)
- Productionofmiceentirelyderivedfromembryonicstem(ES)cellwithmanypassagesbycocultureofEScellswithcytochalasinBinducedtetraploidembryos:O.Ueda;Exp.Anim.44,205(1995)
- TheinhibitionofGLUT1glucosetransportandcytochalasinBbindingactivitybytricyclicantidepressants:H.B.Pinkofsky,etal.;Life.Sci. 66,271(2000)
- Cytokinesis-blockmicronucleuscytomeassay:M.Fenech;Nat.Protocols2,1084(2007)
- ThechemistryandBIOLOGyofcytochalasans:K.Scherlach,etal.;Nat.Prod.Rep.27,869(2010)(Review)
- CytochalasinBtreatmentofmouseoocytesduringintracytoplasmicsperminjection(ICSI)increasesembryosurvivalwithoutimpairmentofdevelopment:L.L.Hu,etal.;Zygote20,361(2012)
- CytochalasinBinducesapoptosisthroughthemitochondrialapoptoticpathwayinHeLahumancervicalcarcinomacells:J.Hwang,etal.;Oncol.Rep.30,1929(2013)
- Preparation,InVivoAdmiNISTration,Dose-LimitingToxicities,andAntineoplasticActivityofCytochalasinB:M.Trendowski,etal.;Transl.Oncol.8,308(2015)
- MechanismsunderlyingeffectofthemycotoxincytochalasinBoninductionofcytotoxicity,modulationofcellcycle,Ca2+homeostasisandROSproductioninhumanbreastcells:H.T.Chang,etal.;Toxicol.31,1(2016)
- EffectsofcytochalasinBonDNAmethylationandhistonemodificationinparthenogeneticallyactivatedporcineembryos:X.Hou,etal.;Reproduction152,519(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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