Adipogen/Cyclosporin A/AG-CN2-0079-G001/1 g
商品编号：
AG-CN2-0079-G001
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AntibioticS7481F1;CiclosporinA;CsA;Cyclosporine;NSC290193;RamihyphinA |
| ProductType | Chemical |
| Properties | |
| Formula | C62H111N11O12 |
| MW | 1202.6 |
| MerckIndex | 14:2752 |
| CAS | 59865-13-3 |
| RTECS | GZ4120000 |
| Source/HostChemicals | IsolatedfromTolypoclADIuminflatum. |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,ethanol,methanol,dichlormethane,chloroformoracetone.Insolubleinwater. |
| InChiKey | PMATZTZNYRCHOR-VPYFBNRVBI |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentimmunosuppressant(sameasFK-506(Prod.No.AG-CN2-0047)andrapamycin(Prod.No.AG-CN2-0025)).
- Formsacomplexwithcyclophilin.Inhibitstheactivityofthecalcium/calmodulin-dependentproteinphosphatase2B(PP2B;calcineurin).PreventsthedephosphorylationofnuclearfactorofactivatedTcells(NFAT)transcriptionfactor,leadingtodisruptionofTcellactivation.
- SuppressesproliferationofcytotoxicTcellsandinhibitstheproductionofTcell-derivedmediatorssuchasinterleukin-2(IL-2).
- Preventsrejectionoftransplantedorgans.
- Anti-inflammatorycompoundinthetreatmentofseveralinflammatoryskindiseases(e.g.atopicdermatitis)andwithpotentialanti-rheumaticactivity(rheumatoidarthritis).
- Antibacterial.Antifungal.Antiparasitic.
- Apoptosisinhibitor.Inhibitsthemitochondrialpermeabilitytransitionpore(MPTP)fromopening,thusinhibitingcytochromecrelease.
- NF-κBsuppressorbyinductionofunfoldedproteinresponse(UPR).
- Anti-cancercompound.Apoptosisandautophagyinducer.
- Inhibitsnitricoxidesynthesisinducedbyinterleukin-1α,lipopolysaccharidesandTNF-α.
- PotentlyinduceshighlycardiogenicProgenitorsfromembryonicstem(ES)cells.
ProductReferences
- CalcineurinphosphataseactivityinTlymphocytesisinhibitedbyFK506andcyclosporinA:D.A.Fruman,etal.;PNAS89,3686(1992)
- CyclosporinA,FK506andrapamycin:morethanjustimmunosuppression:J.Kunz&M.N.Hall;TIBS 18, 334(1993)
- CyclosporinAandFK506:molecularmechanismsofimmunosuppressionandprobesfortransplantationBIOLOGy:B.E.Bierer,etal.;Curr.Opin.Immunol. 5, 763(1993)
- ImmunologicalactionsofcyclosporinAinrheumatoidarthritis:D.Yocum;Br.J.Rheumatol.32,38(1993)
- Theantimicrobialactivitiesofcyclosporine,FK506,andrapamycin:H.P.High;Tansplantation57,1689(1994)(Review)
- Identificationofimmunosuppressant-inducedapoptosisinamurineB-celllineanditspreventionbybcl-xbutnotbcl-2:A.R.Gottschalk,etal.;PNAS91,7350(1994)
- InhibitionofthemitochondrialpermeabilitytransitionporebycyclosporinAduringlongtimeframeexperiments:relationshipbetweenporeopeningandtheactivityofmitochondrialphospholipases.K.M.Broekemeier&D.R.Pfeiffer;Biochemistry34,16440(1995)
- EffectsofcyclosporinAandFK506onnitricoxideandtetrahydrobiopterinsynthesisinbacteriallipopolysaccharide-treatedJ774macrophages:Y.Hattori&N.Naranishi;CellImmunol.165,7(1995)
- InhibitionofTlymphocyteactivationandapoptoticcelldeathbycyclosporinAandtacrolimus(FK506).ItsrelevancetotherapyofHIVinfection:A.W.Thomson&C.A.Bonham;Adv.Exp.Med.Biol.374,211(1995)(Review)
- FK506inthetreatmentofinflammatoryskindisease:promisesandperspectives:G.Michel,etal.;Immunol.Today 17, 106(1996)(Review)
- TheantiparasiteeffectsofcyclosporinA:possIBLedrugtargetsandclinicalapplications:A.Bell,etal.;Gen.Pharmacol.27,963(1996)(Review)
- ThemechanismofactionofcyclosporinAandFK506:S.Ho,etal.;Clin.Immunol.Immunopathol. 80, S40(1996)(Review)
- Calcineurinphosphataseactivityandimmunosuppression.AreviewontheroleofcalcineurinphosphataseactivityandtheimmunosuppressiveeffectofcyclosporinAandtacrolimus:K.A.Jorgensen,etal.;Scand.J.Immunol.57,93(2003)(Review)
- SuppressionofNF-kappaBbycyclosporinAandtacrolimus(FK506)viainductionoftheC/EBPfamily:implicationforunfoldedproteinresponse:S.Du,etal.;J.Immunol. 182, 7201(2009)
- MelatoninsuppressescyclosporineA-inducedautophagyinratpituitaryGH3cells:Y.M.Yoo&E.B.Jeung;J.PinealRes.48,204(2010)
- Cyclosporin-Apotentlyinduceshighlycardiogenicprogenitorsfromembryonicstemcells:P.Yan,etal.;BBRC379,115(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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