Adipogen/Cyclopamine/AG-CN2-0028-M005/5 mg
商品编号：
AG-CN2-0028-M005
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 11-Deoxyjervine;11-Deoxojervine;HSDB3505 |
| ProductType | Chemical |
| Properties | |
| Formula | C27H41NO2 |
| MW | 411.6 |
| CAS | 4449-51-8 |
| Source/HostChemicals | IsolatedfromVeratrumcalifornicum. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinethanol,methanol,DMForDMSO.Insolubleinwater. |
| InChiKey | QASFUMOKHFSJGL-LAFRSMQTSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeablesteroidalalkaloid.
- Specificsonichedgehog(Shh)signalingpathwayinhibitor.Directlyinteracts/inhibitsSmo(smoothened)[1-4].
- Teratogenic[1]andantitumorcompound.Inhibitstumorcellgrowthandprogression.ShowsselectiveactivityagainstShh-dependenttumors[5-11].
- BlocksabnormalcellgrowthassociatedwithoncogenicmutationsofPtchandSmoinfibroblasts[2].
- ArrestscellcycleatG0/G1[6].
- Apoptosisinducer[8].
ProductReferences
- TheteratogenicVeratrumalkaloidcyclopamineinhibitssonichedgehogsignaltransduction:J.P.Incardona,etal.;Development125,3553(1998)
- Pancreasdevelopmentispromotedbycyclopamine,ahedgehogsignalinginhibitor:S.K.Kim&D.A.Melton;PNAS95,13036(1998)
- EffectsofoncogenicmutationsinSmoothenedandPatchedcanbereversedbycyclopamine:J.Taipale,etal;Nature406,1005(2000)
- InhibitionofHedgehogsignalingbydirectbindingofcyclopaminetoSmoothened:J.K.Chen,etal.;GenesDev.16,2743(2002)
- Hedgehogsignallingincolorectaltumourcells:inductionofapoptosiswithcyclopaminetreatment:D.Qualtrough,etal.;Int.J.Cancer110,831(2004)
- Thehedgehogpathwayinhibitorcyclopamineincreaseslevelsofp27,anddecreasesbothexpressionofIGF-IIandactivationofAktinPC-3prostatecancercells:R.J.Levitt,etal.;CancerLett.255,300(2007)
- Cyclopamine-mediatedhedgehogpathwayinhibitiondepletesstem-likecancercellsinglioblastoma:E.E.Bar,etal.;StemCells25,2524(2007)
- Thehedgehoginhibitorcyclopamineinducesapoptosisinleukemiccellsinvitro:J.Warzecha,etal.;Leuk.Lymph.49,2383(2008)
- CyclopamineinhibitionofhumanbreastcancercellgrowthindependentofSmoothened(Smo):X.Zhang,etal.;BreastCancerRes.Treat.115,505(2009)
- Cyclopamineandhedgehogsignaling:chemistry,BIOLOGy,medicalperspectives:P.Heretsch,etal.;Chem.Int.Ed.Engl.49,3418(2010) (Review)
- Targetingthehedgehogpathway:thedevelopmentofcyclopamineandthedevelopmentofanti-cancerdrugstargetingthehedgehogpathway:A.Gould&S.Missailidis;MiniRev.Med.Chem.11,200(2011)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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