Adipogen/CX-4945 . hydrochloride/AG-CR1-3629-M005/5 mg
商品编号：
AG-CR1-3629-M005
品牌：
Adipogen Inc
市场价：
¥3300.00
美元价：
1980.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Silmitasertib.HCl;8-Carboxy-N-(3-chlorophenyl)benzo[c][2,6]naphthyridin-5-aminiumchloride |
| ProductType | Chemical |
| Properties | |
| Formula | C19H12ClN3O2.HCl |
| MW | 349.8.36.5 |
| CAS | 1009820-21-6(freeacid) |
| PurityChemicals | ≥98% |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMSO.Insolubleinwater. |
| InChiKey | OBOIGMDUOMSAHW-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Orallyactive,potentandselectiveATP-competitiveinhibitoroftheproteinkinaseCK2(IC50=1nM).
- Anticancercompound.InhibitsproliferationinapanelofcancercelllinesthatoverexpressCK2.Inhibitedmigration,blockssurvivalandinducesapoptosisincancerstemcells,glioblastomasandleukemiacells.
- Showntodecreasetheglucosemetabolismincancercells.
- PotentinhibitorofCdc2-likekinases(Clks)invitro,consequentlyinterferingwithalternativesplicing.
- PotentATP-competitiveinhibitorofDYRK1A(IC50=6.8nM),DYRK1B(IC50=6.4nM)andDYRK3(IC50=18nM),involvedinneurodegeneration-associateddiseases.
- CK2αdeletionselectivelyincreasedM3muscarinicreceptors(M3Rs)-mediatedinsulinsecretionfrompancreaticislets.
- PromotedcAMP-inducedThermogenesisinwhiteADIpocytes.
- CK2inhibitionamelioratesdiet-inducedobesityandinsulinresistanceinmiceinvivobypromotingUCP1-dependentthermogenesis.
ProductReferences
- CX-4945,anorallybioavailableselectiveinhibitorofproteinkinaseCK2,inhibitsprosurvivalandangiogenicsignalingandexhibitsantitumorefficacy:A.Siddiqui-Jain,etal.;CancerRes.70,10288(2010)
- StructuralbasisofCX-4945bindingtohumanproteinkinaseCK2:A.D.Ferguson,etal.;FEBSLett.585,104(2011)
- DiscoveryandSARof5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylicacid(CX-4945),thefirstclinicalstageinhibitorofproteinkinaseCK2forthetreatmentofcancer:F.Pierre,etal.;J.Med.Chem.54,635(2011)
- Pre-clinicalcharacterizationofCX-4945,apotentandselectivesmallmoleculeinhibitorofCK2forthetreatmentofcancer:F.Pierre,etal.;Mol.CellBiochem.356,37(2011)
- CX-4945,aselectiveinhibitorofcaseinkinase-2(CK2),exhibitsanti-tumoractivityinhematologicmalignanciesincludingenhancedactivityinchroniclymphocyticleukemiawhencombinedwithfludarabineandinhibitorsoftheB-cellreceptorpathway:R.C.Prins,etal.;Leukemia27,2094(2013)
- CK2inhibitorCX4945inducessequentialinactivationofproteinsinthesignalingpathwaysrelatedwithcellmigrationandsuppressesmetastasisofA549humanlungcancercells:M.J.Ku,etal.;Bioorg.Med.Chem.Lett.23,5609(2013)
- IdentificationofanovelfunctionofCX-4945asasplicingregulator:H.Kim,etal.;PLosOne9,e94978(2014)
- Activityoftheclinical-stageCK2-specificinhibitorCX-4945againstchroniclymphocyticleukemia:L.R.Martins,etal.;Leukemia28,179(2014)
- PhosphoproteomicsidentifiesCK2asanegativeregulatorofbeigeadipocytethermogenesisandenergyexpenditure:K.Shinoda,etal.;CellMetab.22,997(2015)
- CK2actsasapotentnegativeregulatorofreceptor-mediatedinsulinreleaseinvitroandinvivo:M.Rossi,etal.;PNAS112,E6818(2015)
- Thecaseinkinase2inhibitor,CX-4945,asananti-cancerdrugintreatmentofhumanhematologicalmalignancies:H.J.Chon,etal.;Front.Pharmacol.6,70(2015)
- AchemicalwithprovenclinicalsafetyrescuesDown-syndrome-relatedphenotypesinthroughDYRK1Ainhibition:H.Kim,etal.;Dis.ModelMech.9,839(2016)
- TargetingproteinkinaseCK2suppressesbladdercancercellsurvivalviatheglucosemetabolicpathway:X.Zhang,etal.;Oncotarget7,87361(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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