Adipogen/Curcumin (high purity)/AG-CN2-0059-M250/250 mg
商品编号：
AG-CN2-0059-M250
品牌：
Adipogen Inc
市场价：
¥5300.00
美元价：
3180.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BRN2306965;CCRIS3257;NSC32982;NSC687842;CI75300 |
| ProductType | Chemical |
| Properties | |
| Formula | C21H20O6 |
| MW | 368.4 |
| MerckIndex | 14:2673 |
| CAS | 458-37-7 |
| Source/HostChemicals | Synthetic.Originallyisolatedfromturmeric(Curcumalonga). |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellow-orangecrystallinepowder. |
| Solubility | Solubleinmethanol,ethanol,ethylacetate,acetone,methylenechloride,dimethylformamideormethylethylketone. |
| OtherProductData | Note:Thishighlypurifiedproductisfreeofdemethoxy-andbis-demethoxycurcuminanddoesnotcontain30-40%bioactiveimpurities |
| InChiKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anti-cancercompound.Interfereswithmultiplecellsignalingpathways,includingcellcycle(cyclinD1andcyclinE),apoptosis(activationofcaspasesanddown-regulationofanti-apoptoticgeneproducts),proliferation(HER-2,EGFRandAP-1),survival(PI3K/AKTpathway),invasion(MMP-9andadhesionmolecules),angiogenesis(VEGF),metastasis(CXCR-4)andinflammation(NF-κB,TNF,IL-6,IL-1,COX-2and5-LOX).
- Anti-angiogenic.Anti-metastatic.Anti-invasive.Chemopreventive.
- Sonichedgehog(Shh)signalingpathwaymodulator.DownregulatesShhandGli1.
- Antioxidant.
- Anti-inflammatory.PotentinhibitorofNF-κB,cyclooxygenase-2(COX-2),lipooxygenase(LOX),andinducIBLenitricoxidesynthase(iNOS;NOSII).DownregulatestheexpressionofvariousproinflammatorycytokinesincludingTNF,IL-1,IL-2,IL-6,IL-8,IL-12andchemokines.
- Potentimmunomodulator.
- Modulatesseveralkeytranscriptionfactors.Down-regulatetranscriptionfactorsNF-κB,AP-1andEgr-1.Down-regulatestheexpressionofCOX-2,LOX,NOS,MMP-9,uPA,TNF,chemokines,cellsurfaceadhesionmoleculesandcyclinD1.Down-regulategrowthfactorreceptors(suchasEGFRandHER2)andinhibitstheactivityofc-JunN-terminalkinase,proteintyrosinekinasesandproteinserine/threoninekinases.
- Neuroprotective.Anti-amyloidactivity.
- Cardioprotective.p300/CBP-HATinhibitor.
- Regulateslipidmetabolismanddownregulatesobesity.Activatesperoxisomeproliferator-activatedreceptor-γ(PPARγ)andNrf2cell-signalingpathways.
- Antiviral,antibacterial,antifungal.
- Epigeneticagent.Interactswithhistonedeacetylases(HDACs),histoneacetyltransferases(HATs),DNAmethyltransferaseIandmicroRNAs.
- Proteasomemodulator/inhibitor.
- Inducerofautophagyinlungadenocarcinomacells.
ProductReferences
- Anticancerpotentialofcurcumin:preclinicalandclinicalstudies:B.B.Aggarwal,etal.;AnticancerRes.23,363(2003)(Review)
- Curcumin:thestorysofar:R.A.Sharma,etal.;Eur.J.Cancer41,1955(2005)(Review)
- Curcumin,anatoxicantioxidantandnaturalNFkappaB,cyclooxygenase-2,lipooxygenase,andinduciblenitricoxidesynthaseinhibitor:ashieldagainstacuteandchronicdiseases:S.Bengmark;JPENJ.Parenter.Enteral.Nutr.30,45(2006)(Review)
- MultipleBIOLOGicalactivitiesofcurcumin:ashortreview:R.K.Maheshwari,etal.;LifeSci.78,2081(2006)(Review)
- "Spicingup"oftheimmunesystembycurcumin:G.C.Jagetia&B.B.Aggarwal;J.Clin.Immunol.27,19(2007)(Review)
- Curcumin:theIndiansolidgold:B.B.Aggarwal,etal.;Adv.Exp.Med.Biol.595,1(2007)(Review)
- Antioxidantandanti-inflammatorypropertiesofcurcumin:V.P.Menon&A.R.Sudheer;Adv.Exp.Med.Biol.595,105(2007)(Review)
- Modulationoftranscriptionfactorsbycurcumin:S.Shishodia,etal.;Adv.Exp.Med.Biol.595,127(2007)(Review)
- Antitumor,anti-invasion,andantimetastaticeffectsofcurcumin:G.Kuttan,etal.;Adv.Exp.Med.Biol.595,173(2007)(Review)
- Curcuminasaninhibitorofangiogenesis:S.S.Bhandarkar&J.L.Arbiser;Adv.Exp.Med.Biol.595,185(2007)(Review)
- Neuroprotectiveeffectsofcurcumin:G.M.Cole,etal.;Adv.Exp.Med.Biol.595,197(2007)(Review)
- Immunomodulationbycurcumin:S.C.Gautam,etal.;Adv.Exp.Med.Biol.595,321(2007)(Review)
- Curcuminandcancer:an"old-age"diseasewithan"age-old"solution:P.Anand,etal.;CancerLett.267,133(2008)(Review)
- Potentialtherapeuticeffectsofcurcumin,theanti-inflammatoryagent,againstneurodegenerative,cardiovascular,pulmonary,metabolic,autoimmuneandneoplasticdiseases:B.B.Aggarwal&K.B.Harikumar;Int.J.Biochem.CellBiol.41,40(2009)(Review)
- Theprotectiveroleofcurcuminincardiovasculardiseases:W.Wongcharoen&A.Phrommintikul;Int.J.Cardiol.133,145(2009)(Review)
- REVIEW:CurcuminandAlzheimer"sdisease:T.Hamaguchi,etal.;CNSNeurosci.Ther.16,285(2010)(Review)
- Targetinginflammation-inducedobesityandmetabolicdiseasesbycurcuminandothernutraceuticals:B.B.Aggarwal;Annu.Rev.Nutr.30,173(2010)(Review)
- Developmentofcurcuminasanepigeneticagent:S.Fu&R.Kurzrock;Cancer116,4670(2010)(Review)
- TheroleofnutraceuticalsintheregulationofWntandHedgehogsignalingincancer:F.H.Sarkar,etal.;CancerMetastasisRev.29,383(2010)(Review)
- Curcuminandobesity:evidenceandmechanisms:L.Alappat&A.B.Awad;Nutr.Rev.68,729(2010)(Review)
- Curcumin:ananti-inflammatorymoleculefromacurryspiceonthepathtocancertreatment:P.Basnet&N.Skalko-Basnet;Molecules16,4567(2011)(Review)
- Curcumin:apotentialneuroprotectiveagentinParkinson"sdisease:R.B.Mythri&M.M.Bharath;Curr.Pharm.Des.18,91(2012)(Review)
- CurcumininducesautophagyviaactivatingtheAMPKsignalingpathwayinlungadenocarcinomacells:K.Xiao,etal.;J.Pharmacol.Sci.123,102(2013)
- Targetingproteasomalpathwaysbydietarycurcuminforcancerpreventionandtreatment:N.Hasima&B.B.Aggarwal;Curr.Med.Chem.21,1583(2014)
- CurcuminattenuatesglutamateneurotoxicityinthehippocampusbysuppressionofERstress-associatedTXNIP/NLRP3inflammasomeactivationinamannerdependentonAMPK:Y.Li,etal.;Toxicol.Appl.Pharmacol.286,53(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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