脂肪原/葫芦素E/AG-CN2-0474-M025/25 mg
商品编号：
AG-CN2-0474-M025
品牌：
Adipogen Inc
市场价：
¥11200.00
美元价：
6720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CucE;α-Elaterin;α-Elaterine;NSC106399;BRN2343323 |
| ProductType | Chemical |
| Properties | |
| Formula | C32H44O8 |
| MW | 556.7 |
| CAS | 18444-66-1 |
| Source/HostChemicals | IsolatedfromCucumismeloL. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitepowder. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | NDYMQXYDSVBNLL-MUYMLXPFSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentactindepolymerizationinhibitor.Showntohaveadifferentmechanismofactioncomparedtojasplakinolide(Prod.No.AG-CN2-0037),bindingtoadifferentsite.
- Bindsspecificallytofilamentousactin(F-actin)formingacovalentbondatresidueCys257,stabilizingF-actinwithoutaffectingactinpolymerizationornucleation.Doesnotbindtomonomericactin(G-actin).
- Immunomodulatorwithanti-inflammatoryandanti-tumOrigenicpropertiesinarangeofcancercelllines,mediatedbyitsactiononthecellularCytoskeleton,onmitoticpathwaysaswellasoncellularautophagy.
- Showntoinduceapoptosis,autophagyandcellcyclearrestatG2/M.InhibitstumorangiogenesisthroughJak-STAT3signalingpathway,suppressescellmigrationandinvasion,andinhibitsNF-κBnucleartranslocation.
- Antioxidantandpotentialneuroprotectivecompoundwithpotentialneurodegenerativeproperties.
ProductReferences
- CucurbitacinE-induceddisruptionoftheactinandvimentincytoskeletoninprostatecarcinomacells:K.L.Duncan,etal.;Biochem.Pharmacol.52,1553(1996)
- Cucurbitacinglucosides:antioxidantandfree-rADIcalscavengingactivities:T.Tannin-Spitz,etal.;BBRC364,181(2007)
- DirectinteractionofCucurbitacinEisolatedfromAlsomitramacrocarpatoactinfilament:K.Momma,etal.;Cytotechnology56,33(2008)
- CucurbitacinE,atetracyclictriterpenescompoundfromChinesemedicine,inhibitstumorangiogenesisthroughVEGFR2-mediatedJak2-STAT3signalingpathway:Y.Dong,etal.;Carcinogenesis31,2097(2010)
- CucurbitacinEInducesG(2)/MPhaseArrestthroughSTAT3/p53/p21SignalingandProvokesApoptosisviaFas/CD95andMitochondria-DependentPathwaysinHumanBladderCancerT24Cells:W.W.Huang,etal.;Evid.BasedComplementAlternat.Med.2012,952762(2012)
- ThenaturalproductcucurbitacinEinhibitsdepolymerizationofactinfilaments:P.M.Soerensen,etal.;ACSChem.Biol.7,1502(2012)
- CucurbitacinEinhibitsbreasttumormetastasisbysuppressingcellmigrationandinvasion:T.Zhang,etal.;BreastCancerRes.Treat.135,445(2012)
- CucurbitacinEexhibitsanti-inflammatoryeffectinRAW264.7cellsviasuppressionofNF-κBnucleartranslocation:J.Qiao,etal.;Inflamm.Res.62,461(2013)
- CucurbitacinEasinducerofcelldeathandapoptosisinhumanoralsquamouscellcarcinomacelllineSAS:C.M.Hung,etal.;Int.J.Mol.Sci.14,17147(2013)
- CucurbitacinEhasneuroprotectivepropertiesandautophagicmodulatingactivitiesondopaminergicneurons:A.M.Arel-Dubeau,etal.;Oxid.Med.CellLongev.2014,425496(2014)
- InducementofmitosisdelaybycucurbitacinE,anoveltetracyclictriterpenefromclimbingstemofCucumismeloL.,throughGADD45γinhumanbrainmalignantglioma(GBM)8401cells:Y.C.Hsu,etal.;CellDeathDis.5,e1087(2014)
- CucurbitacinEInducesAutophagyviaDownregulatingmTORC1SignalingandUpregulatingAMPKActivity:Q.B.Zha,etal.;PLoSOne10,e0124355(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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