Adipogen/Cucurbitacin B/AG-CN2-0472-M025/25 mg
商品编号：
AG-CN2-0472-M025
品牌：
Adipogen Inc
市场价：
¥11200.00
美元价：
6720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CucB;1,2-Dihydro-α-elaterin;Amarine;NSC49451;NSC144154 |
| ProductType | Chemical |
| Properties | |
| Formula | C32H46O8 |
| MW | 558.7 |
| CAS | 6199-67-3 |
| Source/HostChemicals | IsolatedfromCucumismeloL. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitepowder. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | IXQKXEUSCPEQRD-DKRGWESNSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Microtubulepolymerizationinhibitor.DisruptsF-actinandinducesnucleophosmin/B23translocation.
- Immunomodulatorwithantimicrobial,anti-inflammatoryandantitumOrigenicproperties.
- Inducesapoptosis,autophagyandcellcyclearrestatG2/Mphaseinarangeofcancercelllines.
- ShowntoinhibitSTAT3phosphorylationandexpressionlevelsandblocksJAK2activity,aswellasthetranscriptionalactivityofHIF1αandNF-κB.
- Antioxidant.
- ServesasanecdysteroidreceptorantagoNISTinDrosophila.
ProductReferences
- Cucurbitacinsareinsectsteroidhormoneantagonistsactingattheecdysteroidreceptor:L.Dinan,etal.;Biochem.J.327,643(1997)
- Cucurbitacinglucosides:antioxidantandfree-rADIcalscavengingactivities:T.Tannin-Spitz,etal.;BBRC364,181(2007)
- CucurbitacinBinducesdifferentiation,cellcyclearrest,andactincytoskeletalalterationsinmyeloidleukemiacells:T.Haritunians,etal.;Leuk.Res.32,1366(2008)
- CucurbitacinBmarkedlyinhibitsgrowthandrapidlyaffectstheCytoskeletoninglioblastomamultiforme:D.Yin,etal.;Int.J.Cancer123,1364(2008)
- CucurbitacinBhasapotentantiproliferativeeffectonbreastcancercellsinvitroandinvivo:N.Wakimoto,etal.;CancerSci.99,1793(2008)
- CucurbitacinBinhibitsSTAT3andtheRaf/MEK/ERKpathwayinleukemiacelllineK562:K.T.Chan,etal.;CancerLett.289,46(2010)
- CucurbitacinBinducesrapiddepletionoftheG-actinpoolthroughreactiveoxygenspecies-dependentactinaggregationinmelanomacells:Y.Zhang,etal.;ActaBiochim.Biophys.Sin.(Shanghai)43,556(2011)
- InhibitionofWntsignalingbycucurbitacinBinbreastcancercells:reductionofWnt-associatedproteinsandreducedtranslocationofgalectin-3-mediatedβ-catenintothenucleus:S.Dakeng,etal.;J.CellBiochem.113,49(2012)
- CucurbitacininducesautophagythroughmitochondrialROSproductionwhichcounteractstolimitcaspase-dependentapoptosis:T.Zhang,etal.;Autophagy8,559(2012)
- CucurbitacinBinhibitshumanbreastcancercellproliferationthroughdisruptionofmicrotubulepolymerizationandnucleophosmin/B23translocation:S.Duangmano,etal.;BMCComplement.Altern.Med.12,185(2012)
- CucurbitacinBinhibitsthetranslationalexpressionofhypoxia-inducIBLefactor-1α:J.Ma,etal.;Eur.J.Pharmacol.723,46(2014)
- CucurbitacinBinducesDNAdamage,G2/Mphasearrest,andapoptosismediatedbyreactiveoxygenspecies(ROS)inleukemiaK562cells:J.Guo,etal.;AnticancerAgentsMed.Chem.14,1146(2014)
- CucurbitacinBinhibitsproliferationandinducesapoptosisviaSTAT3pathwayinhibitioninA549lungcancercells:M.Zhang,etal.;Mol.Med.Rep.10,2905(2014)
- InhibitoryeffectofcucurbitacinBonimiquimod-inducedskininflammation:Z.J.Li,etal.;BBRC459,673(2015)
- CucurbitacinBinhibitsimmunomodulatoryfunctionandtheinflammatoryresponseinmacrophages:M.Kim,etal.;Immunopharmacol.Immunotoxicol.37,473(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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