Adipogen/Cucurbitacin B/AG-CN2-0472-M001/1 mg
商品编号：
AG-CN2-0472-M001
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Cuc B; 1,2-Dihydro-α-elaterin; Amarine; NSC 49451; NSC 144154 |
| Product Type | Chemical |
| Properties | |
| Formula | C32H46O8 |
| MW | 558.7 |
| CAS | 6199-67-3 |
| Source/Host Chemicals | Isolated from Cucumis melo L. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | IXQKXEUSCPEQRD-DKRGWESNSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation.
- Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties.
- Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell lines.
- Shown to inhibit STAT 3 phosphorylation and expression levels and blocks JAK2 activity, as well as the transcriptional activity of HIF1α and NF-κB.
- Antioxidant.
- Serves as an ecdysteroid receptor antagonist in Drosophila.
Product References
- Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor: L. Dinan, et al.; Biochem. J. 327, 643 (1997)
- Cucurbitacin glucosides: antioxidant and free-radical scavenging activities: T. Tannin-Spitz, et al.; BBRC 364, 181 (2007)
- Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells: T. Haritunians, et al.; Leuk. Res. 32, 1366 (2008)
- Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme: D. Yin, et al.; Int. J. Cancer 123, 1364 (2008)
- Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo: N. Wakimoto, et al.; Cancer Sci. 99, 1793 (2008)
- Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562: K.T. Chan, et al.; Cancer Lett. 289, 46 (2010)
- Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells: Y. Zhang, et al.; Acta Biochim. Biophys. Sin. (Shanghai) 43, 556 (2011)
- Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus: S. Dakeng, et al.; J. Cell Biochem. 113, 49 (2012)
- Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis: T. Zhang, et al.; Autophagy 8, 559 (2012)
- Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation: S. Duangmano, et al.; BMC Complement. Altern. Med. 12, 185 (2012)
- Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α: J. Ma, et al.; Eur. J. Pharmacol. 723, 46 (2014)
- Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells: J. Guo, et al.; Anticancer Agents Med. Chem. 14, 1146 (2014)
- Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells: M. Zhang, et al.; Mol. Med. Rep. 10, 2905 (2014)
- Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation: Z.J. Li, et al.; BBRC 459, 673 (2015)
- Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages: M. Kim, et al.; Immunopharmacol. Immunotoxicol. 37, 473 (2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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