脂肪原/刀豆霉素B（高纯度）/BVT-0253-C100/100µg
商品编号：
BVT-0253-C100
品牌：
Adipogen Inc
市场价：
¥3000.00
美元价：
1800.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 8-Deethyl-8-methylconcanamycinA |
| ProductType | Chemical |
| Properties | |
| Formula | C45H73NO14 |
| MW | 852.1 |
| CAS | 81552-33-2 |
| Source/HostChemicals | IsolatedfromStreptomycessp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,chloroform,acetonitrileormethanol;insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | AQXXGIBOZQZSAT-UZYXLCJWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- ExhibitssimilaractivityasconcanamycinA(Prod.No.BVT-0237)andconcanamycinC(Prod.No.BVT-0254).
- Specificvacuolar-typeH+-ATPaseinhibitor.
- InhibitorofautophagicdegradationbyrisinglysosomalpHandthusinactivatingthelysosomalacidhydrolases.
- Suppressesboneresorption.
- Inhibitsproliferationofmousespleniclymphocytes.
- Antifungalandlarvicidal.
ProductReferences
- StructuresofconcanamycinsBandC:H.Kinashi,etal.;J.Antibiot.35,1618(1982)
- IsolationandcharacterizationofconcanamycinsA,BandC:H.Kinashi,etal.;J.Antibiot.(Tokyo)37,1333(1984)
- InvolvementofthevacuolarH(+)-ATPasesinthesecretorypathwayofHepG2cells:M.Yilla,etal.;J.Biol.Chem.268,19092(1993)
- InhibitoryeffectofmodifiedbafilomycinsandconcanamycinsonP-andV-typeadenosintriphosphatase:S.Drose,etal.;Biochemistry32,3902(1993)
- CharacterizationoftheATPaseactivityofP-glycoproteinfrommultidrug-resistantChinesehamsterovarycells:F.J.Sharom,etal.;Biochem.J.308(Pt2),381(1995)
- ConcanamycinBinhibitstheexpressionofnewlysynthesizedMHCclassIImoleculesonthecellsurface:K.Ito,etal.;J.Antibiot.48,488(1995)
- ConcanamycinB,avacuolarH(+)-ATPasespecificinhibitorsuppressesboneresorptioninvitro:J.T.Woo,etal.;Biol.Pharm.Bull.19,297(1996)
- Invivorapidreductionofalloantigen-activatedCD8+maturecytotoxicTcellsbyinhibitorsofacidificationofintracellularorganelles,prodigiosin25-CandconcanamycinB:M.H.Lee,etal.;Immunology99,243(2000)
- VacuolarH+-ATPaseinhibitorsovercomeBcl-xL-mediatedchemoresistancethroughrestorationofacaspase-independentapoptoticpathway:Y.Sasazawa,et.al.;CancerSci.100,1460(2009)
- InhibitorsoftheV0subunitofthevacuolarH+-ATPasepreventsegregationoflysosomal-andsecretory-pathwayproteins:J.A.Sobota,et.al.;J.CellSci.122,3542(2009)
- InhibitorsofV-ATPase:oldandnewplayers:M.Huss,et.al.;J.Exp.Biol.212,341(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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