Adipogen/Concanamycin A (high purity)/BVT-0237-M001/1 mg
商品编号：
BVT-0237-M001
品牌：
Adipogen Inc
市场价：
¥11000.00
美元价：
6600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Folimycin;AntibioticTAN1323B;AntibioticX4357B |
| ProductType | Chemical |
| Properties | |
| Formula | C46H75NO14 |
| MW | 866.1 |
| CAS | 80890-47-7 |
| RTECS | CB9732000 |
| Source/HostChemicals | IsolatedfromStreptomycessp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinmethanol,DMSOoracetonitrile;insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | DJZCTUVALDDONK-MSPZYORZSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- MorepotentandspecificH+-ATPaseinhibitorthanbafilomycinA1(Prod.No.BVT-0252).
- InhibitsacidificationoforganellessuchaslysosomesandtheGolgiapparatus.
- InhibitorofautophagicdegradationbyrisinglysosomalpHandthusinactivatingthelysosomalacidhydrolases.
- Blockscellsurfaceexpressionofviralglycoproteinswithoutaffectingtheirsynthesis.
- Cytotoxicinanumberofcelllinesinacellviabilityassay.
- Inducesnitricoxide(NO)production.
ProductReferences
- IsolationandcharacterizationofconcanamycinsA,BandC:H.Kinashi,etal.;J.Antibiot.37,1333(1984)
- Folimycin(concanamycinA),aspecificinhibitorofV-ATPase,blocksintracellulartranslocationoftheglycoproteinofvesicularstomatitisvirusbeforearrivaltotheGolgiapparatus:M.Muroi,etal.;CellStruct.Funct.18,139(1993)
- Folimycin(concanamycinA),aninhibitorofV-typeH(+)-ATPase,blockscell-surfaceexpressionofvirus-envelopeglycoproteins:M.Muroi,etal.;BBRC193,999(1993)
- InhibitoryeffectofmodifiedbafilomycinsandconcanamycinsonP-andV-typeadenosinetriphosphatases:S.Drose,etal.;Biochemistry32,3902(1993)
- InvolvementofthevacuolarH(+)-ATPasesinthesecretorypathwayofHepG2cells:M.Yilla,etal.;J.Biol.Chem.268,19092(1993)
- CharacterizationoftheATPaseactivityofP-glycoproteinfrommultidrug-resistantChinesehamsterovarycells:F.J.Sharom,etal.;Biochem.J.308(Pt2),381(1995)
- SpecificinhibitorsofvacuolartypeH(+)-ATPasesinduceapoptoticcelldeath:T.Nishihara,etal.;BBRC212,255(1995)
- ConcanamycinA,thespecificinhibitorofV-ATPases,bindstotheV(o)subunitc:M.Huss,etal.;J.Biol.Chem.277,40544(2002)
- Nitricoxideproductionbythevacuolar-type(H+)-ATPaseinhibitorsbafilomycinA1andconcanamycinAanditspossIBLeroleinapoptosisinRAW264.7cells:J.Hong,etal.;J.Pharmacol.Exp.Ther.319,672(2006)
- DegradationofoxidizedproteinsbyautophagyduringoxidativestressinArabidopsis:Y.Xiong,etal.;PlantPhysiol.143,291(2007)
- InhibitorsoftheV0subunitofthevacuolarH+-ATPasepreventsegregationoflysosomal-andsecretory-pathwayproteins:J.A.Sobota,etal.;J.CellSci.122,3542(2009)
- InhibitorsofV-ATPase:oldandnewplayers:M.Huss,etal.;J.Exp.Biol.212,341(2009)
- Increasedproductionofreactiveoxygenspeciesbythevacuolar-type(H+)-ATPaseinhibitorsbafilomycinA1andconcanamycinAinRAW264cells:A.Yokomakura,etal.;J.Toxicol.Sci.37,1045(2012)
- InhibitionofvacuolarATPaseattenuatestheTRAIL-inducedactivationofcaspase-8andmodulatesthetraffickingofTRAILreceptosomes:V.Horova,etal.;FEBSJ.280,3436(2013)
- Estimatingtherotationrateinthevacuolarproton-ATPaseinnativeyeastvacuolarmembranes:Z.Ferencz,etal.;Eur.Biophys.J.42,147(2013)
- InhibitorsofvacuolarATPaseprotonpumpsinhibithumanprostatecancercellinvasionandprostate-specificantigenexpressionandsecretion:V.Michel,etal.;Int.J.Cancer132,E1(2013)
- LossofvacuolarH+-ATPaseactivityinorganellessignalsubiquitinationandendocytosisoftheyeastplasmamembraneprotonpumpPma1p:A.M.Smardon&P.M.Kane;J.Biol.Chem.289,32316(2014)
- CombinedeffectsofEGFRtyrosinekinaseinhibitorsandvATPaseinhibitorsinNSCLCcells:H.Jin,etal.;Toxicol.Appl.Pharm.278,17(2015)
- AppropriatevacuolaracidificationinSaccharomycescerevisiaeisassociatedwithefficienthighsugarfermentation:T.D.Nguyen,etal.;FoodMicroBIOLOGy70,262(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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