Adipogen/Compound E/AG-CR1-0081-M001/1 mg
商品编号：
AG-CR1-0081-M001
品牌：
Adipogen Inc
市场价：
¥3800.00
美元价：
2280.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | γ-SecretaseInhibitorXXI;(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide |
| ProductType | Chemical |
| Properties | |
| Formula | C27H24F2N4O3 |
| MW | 490.5 |
| CAS | 209986-17-4 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | JNGZXGGOCLZBFB-IVCQMTBJSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potent,selective,non-transitionstateandnon-competitiveγ-secretaseinhibitor.
- Notchprocessinginhibitor.
- Onlyweaklyaffectspresenilinaseactivity.
ProductReferences
- Presenilin-1and-2aremoleculartargetsforgamma-secretaseinhibitors:D.Seiffert,etal.;J.Biol.Chem.275,34086(2000)
- Presenilin-dependentgamma-secretaseactivitymodulatesthymocytedevelopment:P.Doerfler,etal.;PNAS98,9312(2001)
- Pharmacologicalknock-downofthepresenilin1heterodimerbyanovelgamma-secretaseinhibitor:implicationsforpresenilinBIOLOGy:D.Beher,etal.;J.Biol.Chem.276,45394(2001)
- gamma-SecretasecleavageandnuclearlocalizationofErbB-4receptortyrosinekinase:C.Y.Ni,etal.;Science294,2179(2001)
- Regulatedintramembraneproteolysisofthep75neurotrophinreceptormodulatesitsassociationwiththeTrkAreceptor:K.M.Jung,etal.;J.Biol.Chem.278,42161(2003)
- Identificationofanewpresenilin-dependentzeta-cleavagesitewithinthetransmembranedomainofamyloidprecursorprotein:G.Zhao,etal.;J.Biol.Chem.279,50647(2004)
- ActivatingmutationsofNOTCH1inhumanTcellacutelymphoblasticleukemia:A.P.Weng,etal.;Science306,269(2004)
- Determinationofguinea-pigcorticalgamma-secretaseactivityexvivofollowingthesystemicadmiNISTrationofagamma-secretaseinhibitor:S.Grimwood,etal.;Neuropharmacology48,1002(2005)
- Jagged/NotchsignallingisrequiredforasubsetofTGFβ1responsesinhumankidneyepithelialcells:K.C.Nyhan,etal.;Biochim.Biophys.Acta1803,1386(2010)
- Investigatingtheamyloid-betaenhancingeffectofcGMPinneuro2acells:E.Calcagno,etal.;Mech.AgeingDev.166,1(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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