Adipogen/Colistin sulfate (Ph. Eur. Grade)/AG-CN2-0512-G005/5 g
商品编号：
AG-CN2-0512-G005
品牌：
Adipogen Inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Polymyxin E; Belcomycin; Colimycin |
| Product Type | Chemical |
| Properties | |
| Formula | 2(C52H98N16O13) . 5(H2SO4) (unspec.) |
| MW | 2801.7 |
| CAS | 1264-72-8 |
| RTECS | TR1500000 |
| Source/Host Chemicals | Isolated from Bacillus polymyxa. |
| Purity Chemicals | >77% (Mixture, primarly colistin A and B). |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water. |
| Biological Activity | Potency (dry basis) ≥19900U/mg |
| Other Product Data |
Specifications: pH: 4.0 - 6.0 Loss of Drying: <3.5% Related Substance Impurities: <4.0% Total Impurities: <23.0% |
| InChi Key | YKQOSKADJPQZHB-QNPLFGSASA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Very potent polymyxin antibiotic.
- Has only one amino acid difference compared to polymyxin B.
- Antimicrobial.
- Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death.
- Used against multidrug-resistant Gram-negative bacterial infections.
Product References
- Antimicrobial drugs, microorganisms, and phagocytes: P.J. van den Broek; Rev. Infect. Dis. 11, 213 (1989) (Review)
- Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999) (Review)
- The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001) (Review)
- Update on antimicrobial agents: new indications of older agents: T.R. Pasquale & J.S. Tan; Expert Opin. Pharmacother. 6, 1681 (2005) (Review)
- Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections: J. Li, et al.; Lancet Infect. Dis. 6, 589 (2006) (Review)
- Polymyxin B: similarities to and differences from colistin (polymyxin E): A. Kwa, et al.; Expert Rev. Anti. Infect. Ther. 5, 811 (2007) (Review)
- Colistin in the 21st century: R.L. Nation & J. Li; Curr. Opin. Infect. Dis. 22, 535 (2009) (Review)
- New information about the polymyxin/colistin class of antibiotics: J. Molina, et al.; Expert Opin. Pharmacother. 10, 2811 (2009) (Review)
- Colistin: new lessons on an old antibiotic: D. Yahav, et al.; Clin. Microbiol. Infect. 18, 18 (2012) (Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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