Adipogen/Colchicine/AG-CN2-0048-M500/500 mg
商品编号：
AG-CN2-0048-M500
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC757;EINECS200-598-5 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H25NO6 |
| MW | 399.4 |
| MerckIndex | 14:2471 |
| CAS | 64-86-8 |
| RTECS | GH0700000 |
| Source/HostChemicals | IsolatedfromColchicumautumnale. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solublein100%ethanol(>100mg/ml),DMSO(>100mg/ml),waterorDMF. |
| Identity | Determinedby1H-NMR13C-NMR. |
| InChiKey | IAKHMKGGTNLKSZ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anti-cancercompound[5].
- Microtubuleassemblyinhibitor.Depolymerizesmicrotubulesandlimitsmicrotubuleformation(inactivatesspindlefibreformation)[1,2,5,6].
- Inhibitsmitosisduringcelldivisionatmetaphasebyinhibitingspindleformation[6].
- Anti-inflammatorycompound[7,9].Suppressesmonosodiumuratecrystal-inducedNLRP3/NALP3inflammasome-drivencaspase-1activation,IL-1βprocessingandrelease,andL-selectinexpressiononneutrophilsatmicromolarconcentrations.Blocksthereleaseofacrystal-derivedchemotacticfactorfromneutrophillysosomes,blocksneutrophiladhesionto,andinhibitsmonosodiumuratecrystal-inducedproductionofsuperoxideanionsfromneutrophilsatnanomolarconcentrations[7].
- Drugusedintreatmentofgout,familialMediterraneanfever,pericarditisandBehect"sdisease.Investigatedforitsanti-canceractivity[5,8,9].Ithasanarrowtherapeuticindexwithnoclear-cutdistinctionbetweennontoxic,toxicandlethaldoses,causingsubstantialconfusionamongclinicians[8].
- Apoptosisinducerinavarietyofnormalandtumorcelllines[3,4].
- Inhibitorofautophagosome-lysosomefusion.
- Inhibitsacetylateda-tubulinmediateddyneindependenttransportofmitochondriaandsubsequentappositionofASConmitochondriatoNLRP3ontheendoplasmicreticulum invitroandinvivo.
ProductReferences
- Interactionsofcolchicinewithtubulin:S.B.Hastie;Pharmacol.Ther.51,377(1991)(Review)
- Analysisofthecolchicine-bindingsiteofbeta-tubulin:R.G.Burns;FEBSLett.297,205(1992)(Review)
- Colchicineinducesapoptosisincerebellargranulecells:E.Bonfoco,etal.;Exp.Cell.Res.218,189(1995)
- SustainedJNKactivationinducesendothelialapoptosis:studieswithcolchicineandshearstress:Y.L.Hu,etal.;Am.J.Physiol.277,H1593(1999)
- Microtubulesasatargetforanticancerdrugs:M.A.Jordan&L.Wilson;Nat.Rev.Cancer4,253(2004)
- Anti-mitoticactivityofcolchicineandthestructuralbasisforitsinteractionwithtubulin:B.Bhattacharyya,etal.;Med.Res.Rev.28,155(2008)(Review)
- Colchicine:itsmechanismofactionandefficacyincrystal-inducedinflammation:G.Nuki;Curr.Rheumatol.Rep.10,218(2008)(Review)
- Colchicinepoisoning:thedarksideofanancientdrug:Y.Finkelstein,etal.;Clin.Toxicol.(Phila).48,407(2010)(Review)
- Colchicineforthetreatmentofgout:P.Richette&T.Bardin;ExpertOpin.Pharmacother.11,2933(2010)(Review)
- Microtubule-drivenspatialarrangementofmitochondriapromotesactivationoftheNLRP3inflammasome:T.Misawa,etal.;Nat.Immunol.14,454(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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