Adipogen/Citrinin/AG-CN2-0101-M025/25 mg
商品编号：
AG-CN2-0101-M025
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | NSC 186; BRN 0088597; Antimycin |
| Product Type | Chemical |
| Properties | |
| Formula | C13H14O5 |
| MW | 250.3 |
| Merck Index | 14: 2327 |
| CAS | 518-75-2 |
| RTECS | DJ2275000 |
| Source/Host Chemicals | Isolated from Penicillium citrinum strain FKI-4836. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in methanol, ethanol, methylene chloride, pyridine or dioxane. Insoluble in water, chloroform or hexane. |
| Declaration | Manufactured by BioLinks K.K. with courtesy strain from The Kitasato Institute. |
| Other Product Data | Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9). |
| InChi Key | CQIUKKVOEOPUDV-IYSWYEEDSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic [1, 2].
- Antiprotozoal. Antimicrobial [3, 6].
- Cytotoxic and genotoxic in various mammalian cells [4].
- Mitochondrial permeability transition pore (MPTP) activator [5-7].
- Apoptosis inducer [7-9, 14].
- ERK and JNK signaling pathways activator [10].
- Nephrotoxic mycotoxin [11].
- Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1α and NF-κB signaling pathways [12].
- Tubulin polymerization and mitotic spindle assembly inhibitor [13].
- Increases reactive oxygen species (ROS) [14].
- Induces cell cycle arrest at the G0/G1 and G2/M phase [13,14].
Product References
- Citrinin: T.S. Gore, et al.; Nature 16, 157 (1946)
- Citrinin as an Antibiotic: Y. Wang, et al.; Science 106, 291 (1947)
- Antiprotozoal activity in citrinin: A.W. Hayes, et al.; Bull. Environ. Contam. Toxicol. 15, 429 (1976)
- Cytotoxicity of citrinin in cultured kidney epithelial cell systems: M. Yoneyama, et al.; Ecotoxicol. Environ. Saf. 11, 100 (1986)
- Citrinin-induced mitochondrial permeability transition: E.J. Da Lozzo, et al.; J. Biochem. Mol. Toxicol. 12, 291 (1998)
- Antimicrobial activity of the mycotoxin citrinin obtained from the fungus penicillium citrinum: P.M. Mazumder, et al.; Anc. Sci. Life. 21, 191 (2002)
- Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway: F.Y. Yu, et al.; Toxicol. Lett. 161, 143 (2006)
- Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts: W.H. Chan; Biochem. J. 404, 317 (2007)
- Citrinin induces apoptosis in mouse embryonic stem cells: W.H. Chan; IUBMB Life 60, 171 (2008) (Review)
- Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells: C.H. Chang, et al.; Toxicol. Appl. Pharmacol. 237, 281 (2009)
- Toxicological properties of citrinin: D. Flajs & M. Peraica; Arh. Hig. Rada Toksikol. 60, 457 (2009) (Review)
- The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells: B.H. Liu, et al.; Int. Immunopharmacol. 10, 1608 (2010)
- Mycotoxin citrinin induced cell cycle G2/M arrest and numerical chromosomal aberration associated with disruption of microtubule formation in human cells: C.H. Chang, et al.; Toxicol. Sci. 119, 84 (2011)
- Citrinin-generated reactive oxygen species cause cell cycle arrest leading to apoptosis via the intrinsic mitochondrial pathway in mouse skin: R. Kumar, et al.; Toxicol. Sci. 122, 557 (2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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