Adipogen/Citrinin/AG-CN2-0101-M005/5 mg
商品编号：
AG-CN2-0101-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC186;BRN0088597;Antimycin |
| ProductType | Chemical |
| Properties | |
| Formula | C13H14O5 |
| MW | 250.3 |
| MerckIndex | 14:2327 |
| CAS | 518-75-2 |
| RTECS | DJ2275000 |
| Source/HostChemicals | IsolatedfromPenicilliumcitrinumstrainFKI-4836. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | Solubleinmethanol,ethanol,methylenechloride,pyridineordioxane.Insolubleinwater,chloroformorhexane. |
| Declaration | ManufacturedbyBiOlinksK.K.withcourtesystrainfromTheKitasatoInstitute. |
| OtherProductData | SolutionschangecolorwithchangesinpHfromyellow(pH4.6)tored(pH9.9). |
| InChiKey | CQIUKKVOEOPUDV-IYSWYEEDSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1,2].
- Antiprotozoal.Antimicrobial[3,6].
- Cytotoxicandgenotoxicinvariousmammaliancells[4].
- Mitochondrialpermeabilitytransitionpore(MPTP)activator[5-7].
- Apoptosisinducer[7-9,14].
- ERKandJNKsignalingpathwaysactivator[10].
- Nephrotoxicmycotoxin[11].
- SuppressesNOandiNOSexpressionviainhibitionoftheJAK/STAT-1αandNF-κBsignalingpathways[12].
- Tubulinpolymerizationandmitoticspindleassemblyinhibitor[13].
- Increasesreactiveoxygenspecies(ROS)[14].
- InducescellcyclearrestattheG0/G1andG2/Mphase[13,14].
ProductReferences
- Citrinin:T.S.Gore,etal.;Nature16,157(1946)
- CitrininasanAntibiotic:Y.Wang,etal.;Science106,291(1947)
- Antiprotozoalactivityincitrinin:A.W.Hayes,etal.;Bull.Environ.Contam.Toxicol.15,429(1976)
- Cytotoxicityofcitrinininculturedkidneyepithelialcellsystems:M.Yoneyama,etal.;Ecotoxicol.Environ.Saf.11,100(1986)
- Citrinin-inducedmitochondrialpermeabilitytransition:E.J.DaLozzo,etal.;J.Biochem.Mol.Toxicol.12,291(1998)
- Antimicrobialactivityofthemycotoxincitrininobtainedfromthefunguspenicilliumcitrinum:P.M.Mazumder,etal.;Anc.Sci.Life.21,191(2002)
- CitrinininducesapoptosisinHL-60cellsviaactivationofthemitochondrialpathway:F.Y.Yu,etal.;Toxicol.Lett.161,143(2006)
- Citrinininducesapoptosisviaamitochondria-dependentpathwayandinhibitionofsurvivalsignalsinembryonicstemcells,andcausesdevelopmentalinjuryinblastocysts:W.H.Chan;Biochem.J.404,317(2007)
- Citrinininducesapoptosisinmouseembryonicstemcells:W.H.Chan;IUBMBLife 60,171(2008)(Review)
- ActivationofERKandJNKsignalingpathwaysbymycotoxincitrinininhumancells:C.H.Chang,etal.;Toxicol.Appl.Pharmacol.237,281(2009)
- Toxicologicalpropertiesofcitrinin:D.Flajs&M.Peraica;Arh.Hig.RadaToksikol.60,457(2009)(Review)
- Thefungalmetabolite,citrinin,inhibitslipopolysaccharide/interferon-γ-inducednitricoxideproductioninglomerularmesangialcells:B.H.Liu,etal.;Int.Immunopharmacol.10,1608(2010)
- MycotoxincitrinininducedcellcycleG2/Marrestandnumericalchromosomalaberrationassociatedwithdisruptionofmicrotubuleformationinhumancells:C.H.Chang,etal.;Toxicol.Sci.119,84(2011)
- Citrinin-generatedreactiveoxygenspeciescausecellcyclearrestleADIngtoapoptosisviatheintrinsicmitochondrialpathwayinmouseskin:R.Kumar,etal.;Toxicol.Sci.122,557(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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