Adipogen/Cisplatin/AG-CR1-3590-M250/250 mg
商品编号：
AG-CR1-3590-M250
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | cis-Diamminedichloroplatinum(II);Neoplatin;CDDP;cis-DDP;NSC119875;NK801;TR170 |
| ProductType | Chemical |
| Properties | |
| Formula | Cl2H6N2Pt |
| MW | 300.0 |
| MerckIndex | 14:2317 |
| CAS | 15663-27-1 |
| RTECS | TP2450000 |
| PurityChemicals | ≥98% |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMForDMSO.Sparinglysolubleinwater.Insolubleinethanol. |
| OtherProductData | Note:Inaqueoussolutioncis-transisomerizationofcisplatinoccurs.Isomerizationisincreasedatelevatedtemperatures.StABIlityofcisplatininaqueoussolutionswasenhancedbyincreasingthesodiumchloride(NaCl)concentrationto0.9%andwasadverselyaffectedinalkalinesolutionssuchassodiumbicarbonatesolutions.Further,eventhoughsolubleinDMSO,wedonotrecommendtodissolvecisplatininDMSO.DMSOinsertsitselfintotheligand.Itisrecommendedtoprepareallsolutionsfreshandprotectedfromlight. |
| InChiKey | LXZZYRPGZAFOLE-UHFFFAOYSA-L |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/Stability | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentplatinum-basedantineoplasticagent[1,10].
- Anticancercompound[1].Formsinter-andintrastrandDNAadducts/crosslinks,consequentlyblockingDNAreplicationandtranscriptionandinducingcelldeath[2,12,13,15].
- Nephrotoxicwhenusedinvivo[3].
- Potentchemoimmunotherapeutic.Stimulatestheimmuneresponsesbyactivatingmacrophagesandothercellsoftheimmunesystem[4,6].
- Apoptosisinducerviap53-dependentand-independentmechanisms[5,7,8].
- Inducesapoptosisthroughcaspase-3activationandXIAPexpressioninhibition[9,14].
- Targetsotherproteinsandenzymes[10].
- Non-competitiveNHE-1inhibitor,anarchetypal,membrane-boundmechanosensitivesodium-hydrogeniontransporter[16].
ProductReferences
- Antitumoractionofcis-dichlorobis(methylamine)platinum(II):G.R.Gale,etal.;J.Natl.CancerInst.51,1227(1973)
- Preliminarycharacterizationoftheadductsformedbetweentheantitumorcompoundscis-Pt(NH3)2Cl2andDNA:N.P.Johnson;BBRC104,1394(1982)
- Plasmaplatinumlevels:relationshiptocisplatindoseandnephrotoxicity:A.B.Campbell,etal.;CancerTreat.Rep.67,169(1983)
- Immuneresponseofmiceexposedtocis-diamminedichloroplatinum:O.Bagasra,etal.;CancerImmunol.Immunother.19,142(1985)
- CisplatininducesapersistentactivationofJNKthatisrelatedtocelldeath:I.Sanchez-Perez,etal.;Oncogene16,533(1998)
- Antigenpresentationbycisplatin-activatedmacrophages:roleofsolublefactor(s)andsecondmessengers:R.A.Singh&A.Sodhi;Immunol.CellBiol.76,513(1998)
- Cisplatin-inducedapoptosisinhumanproximaltubularepithelialcellsisassociatedwiththeactivationoftheFas/Fasligandsystem:M.S.Razzaque,etal.;Histochem.CellBiol.111,359(1999)
- Thetyrosinekinasec-Ablregulatesp73inapoptoticresponsetocisplatin-inducedDNAdamage:J.G.Gong,etal.;Nature399,806(1999)
- Cisplatin(CDDP)specificallyinducesapoptosisviasequentialactivationofcaspase-8,-3and-6inosteosarcoma:K.Seki,etal.;CancerChemother.Pharmacol.45,199(2000)
- Whatisthe"best"platinum:cisplatin,carboplatin,oroxaliplatin?J.Lokich;CancerInvest.19,756(2001)
- Biomoleculartargetsforplatinumantitumordrugs:R.N.Bose;MiniRev.Med.Chem.2,103(2002)
- Cisplatin:modeofcytotoxicactionandmolecularbasisofresistance:Z.H.Siddik;Oncogene22,7265(2003)
- Newcluesforplatinumantitumorchemistry:KineticallycontrolledmetalbindingtoDNA:J.Reedijk;PNAS100,3611(2003)
- CisplatininhibitstheexpressionofX-linkedinhibitorofapoptosisproteininhumanLNCaPcells:T.Nomura,etal.;Urol.Oncol.22,453(2004)
- Inhibitionoftranscriptionbyplatinumantitumorcompounds:R.C.Todd&S.J.Lippard;Metallomics1,280(2009)
- Nongenomiceffectsofcisplatin:acuteinhibitionofmechanosensitivetransportersandchannelswithoutactinremodeling:N.Milosavljevic,etal.;CancerRes.70,7514(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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