Adipogen/CHS-828/AG-CR1-0064-M025/25 mg
商品编号：
AG-CR1-0064-M025
品牌：
Adipogen Inc
市场价：
¥5600.00
美元价：
3360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GMX1778;(E)-1-[6-(4-Chlorophenoxy)hexyl]-2-cyano-3-(pyridin-4-yl)guanidine |
| ProductType | Chemical |
| Properties | |
| Formula | C19H22ClN5O |
| MW | 371.9 |
| CAS | 200484-11-3 |
| PurityChemicals | ≥98%(HPLC&NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,100%ethanolordimethylformamide. |
| InChiKey | BOIPLTNGIAPDBY-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antitumorcompound[1,2,8].
- Programmedcelldeathinducer[3-5].
- Cytotoxic[6,7,14].
- Antiproliferative[11].
- p53activator[9].
- IκBkinaseinhibitor[10].
- NF-κBinhibitor[10,12].
- Nampt/visfatininhibitor[13,15,16].
ProductReferences
- CHS828,anovelpyridylcyanoguanidinewithpotentantitumoractivityinvitroandinvivo:P.J.Hjarnaa,etal.;CancerRes.59,5751(1999)
- Novelcyanoguanidineswithpotentoralantitumouractivity:C.Schou,etal.;Bioorg.Med.Chem.Lett.24,3095(1997)
- Temporaleffectsofthenovelantitumourpyridylcyanoguanidine(CHS828)onhumanlymphomacells:P.Martinsson,etal.;Eur.J.Cancer37,260(2001)
- CyanoguanidineCHS828inducesprogrammedcelldeathwithapoptoticfeaturesinhumanbreastcancercellsinvitro:C.M.Hansen,etal.;AnticancerRes.20,4211(2000)
- CelldeathwithatypicalfeaturesinducedbythenovelantitumoraldrugCHS828,inhumanU-937GTBcells:P.Martinsson,etal.;Eur.J.Pharmacol.417,181(2001)
- ModelfortimedependencyofcytotoxiceffectofCHS828invitrosuggeststwodifferentmechanismsofaction:S.B.Hassan,etal.;J.Pharmacol.Exp.Ther.299,1140(2001)
- Actionofanovelanticanceragent,CHS828,onmousefibroblasts:increasedsensitivityofcellslackingpoly(ADP-Ribose)polymerase-1:H.Lövborg,etal.;CancerRes.62,4206(2002)
- APhaseIstudyofCHS828inpatientswithsolidtumormalignancy:P.HovstADIus,etal.;Clin.CancerRes.8,2843(2002)
- Activationofp53proteininnormalandintumorcellsbyanovelanticanceragentCHS828:J.Wojciechowski,etal.;DrugsExp.Clin.Res.29,53(2003)
- AnticanceragentCHS828suppressesnuclearfactor-kappaBactivityincancercellsthroughdownregulationofIKKactivity:L.S.Olsen,etal.;Int.J.Cancer111,198(2004)
- Novelantiproliferativeantitumoragents:M.M.Mader,etal.;Curr.Opin.DrugDiscov.Devel.8,613(2005)
- CHS828killtumourcellsbyinhibitingthenuclearfactor-kappaBtranslocationbutunlikelythroughdown-regulationofproteasome:S.B.Hassan,etal.;AnticancerRes.26,4431(2006)
- AnticanceragentCHS-828inhibitscellularsynthesisofNAD:U.H.Olesen,etal.;BBRC367,799(2008)
- Structure-activityrelationshipanalysisofcytotoxiccyanoguanidines:selectionofCHS828ascandidatedrug:H.Lövborg,etal.;BMCRes.Notes2,114(2009)
- ThesmallmoleculeGMX1778isapotentinhibitorofNAD+biosynthesis:strategyforenhancedtherapyinnicotinicacidphosphoribosyltransferase1-deficienttumors:M.Watson,etal.;Mol.Cell.Biol.29,5872(2009)
- Targetenzymemutationsarethemolecularbasisforresistancetowardspharmacologicalinhibitionofnicotinamidephosphoribosyltransferase:U.H.Olesen,etal.;BMCCancer10,677(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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