Adipogen/Chetomin/BVT-0161-M005/5 mg
商品编号：
BVT-0161-M005
品牌：
Adipogen Inc
市场价：
¥11200.00
美元价：
6720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CTM;Chaetomin;NSC289491;BRN0077366 |
| ProductType | Chemical |
| Properties | |
| Formula | C31H30N6O6S4 |
| MW | 710.9 |
| CAS | 1403-36-7 |
| Source/HostChemicals | IsolatedfromChaetomiumsp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitetofawnsolid. |
| Solubility | SolubleinDMSO,ethylacetateorpyridine;fairlysolubleinmethanolor100%ethanol;insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | ZRZWBWPDBOVIGQ-OKMJTBRXSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfrommoisture. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- InhibitorofHIF-1formationbydisruptingthebindingofp300tobothHIF-1αandHIF-2α.
- HistoneH3K9methyltransferasesG9aandSuv39hinhibitor.
- Tumorgrowthinhibitor.
- Angiogenesisinhibitor.
- Potentimmunosuppressor.
- Antibacterialandantifungal.
- Stronginducerofretinalpigmentepithelium(RPE).
ProductReferences
- Thestructureofchetomin:A.G.McInnes,etal.;JACS98,6741(1976)
- Effectsofchetominongrowthandacidicfermentationproductsofrumenbacteria:W.C.JenandG.A.Jones;Can.J.Microbiol.29,1399(1983)
- ImmunomodulatoryconstituentsfromanAscomycete,Chaetomiumseminudum:H.Fujimoto,etal.;J.Nat.Prod.67,98(2004)
- Smallmoleculeblockadeoftranscriptionalcoactivationofthehypoxia-inducIBLefactorpathway:A.L.Kung,etal.;CancerCell6,33(2004)
- EffectsofHIF-1inhibitionbychetominonhypoxia-relatedtranscriptionandrADIosensitivityinHT1080humanfibrosarcomacells:A.Staab,etal.;BMCCancer7,213(2007)
- Epidithiodiketopiperazinesblocktheinteractionbetweenhypoxia-induciblefactor-1α(HIF-1α)andp300byazincejectionmechanism:K.M.Cook,etal.;J.Biol.Chem.284,26831(2009)
- Directinhibitionofhypoxia-inducibletranscriptionfactorcomplexwithdesigneddimericepidithiodiketopiperazine:K.M.Wang,etal.;JACS131,18078(2009)
- Up-regulationofpro-inflammatorygenesasadaptationtohypoxiainMCF-7cellsandinhumanmammaryinvasivecarcinomamicroenvironment:M.Tafani,etal.;CancerSci.101,1014(2010)
- InhibitionofhistoneH3K9methyltransferasesbygliotoxinandrelatedepipolythiodioxopiperazines:M.Takahashi,etal.,J.Antibiot.65,263(2012)
- Epidithiodiketopiperazines(ETPs)exhibitinvitroantiangiogenicandinvivoantitumoractivitybydisruptingtheHIF-1α/p300complexinapreclinicalmodelofprostatecancer:K.M.Reece,etal.;Mol.Cancer13, 91(2014)
- Small-molecule–directed,efficientgenerationofretinalpigmentepitheliumfromhumanpluripotentstemcells:J.Maruotti,etal.;PNAS112,10950(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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