脂肪原/鹅去氧胆酸/AG-CN2-0410-M500/500 mg
商品编号：
AG-CN2-0410-M500
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CDCA;Ulmenide;Kebilis;Hekbilin;Fluibil;Chenodiol;Anthropodeoxycholicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C24H40O4 |
| MW | 392.6 |
| MerckIndex | 14:2054 |
| CAS | 474-25-9 |
| RTECS | FZ1980000 |
| Source/HostChemicals | Synthetic.Originallyisolatedfrombile. |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Whitetooff-whitecrystallinepowder. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide.Sparinglysolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | RUDATBOHQWOJDD-BSWAIDMHSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cytotoxichydrophobicprimarybileacid[1].
- ActivatoroffarnesoidXreceptor(FXR),anuclearreceptorthatishepatoprotectiveandregulatesbileacidsynthesis(cholesterol7α-hydroxylase(CYP7A1)suppression),conjugationandtransport,aswellasgenesinvolvedinlipidandglucosemetabolismand[4-6,14].
- Bileacid-controlledsignalingpathwaysarepromisingnoveltargetstotreatsuchmetabolicdiseasesasobesity,typeIIdiabetes,insulinresistance,hyperlipidemiaandatherosclerosis[1,8,9,12].
- Inhibitorof5β-reductase(AKR1D1)[10,15].
- PotentselectiveinhibitorofDD2(AKR1C2)[3].
- Potentinhibitorof11β-HSD1dehydrogenase[7].
- ChangestumorcellviabilityviaIL-6pathway[11].
- Anticancercompound.Apoptosisinducer[13].
- Immunosuppressiveandanti-inflammatorycompound.Modulatesoxidativestress[2,16].
- Differentiationregulatorofmouseembryonicstemcells[17].
- Usedfordissolutionofcholesterolgallstones.
ProductReferences
- Bileacidsasdrugs:principles,mechanismsofactionandformulations:A.F.Hofmann;Ital.J.Gastroenterol.27,106(1995)(Review)
- S-adenosil-L-methionineisabletoreversetheimmunosuppressiveeffectsofchenodeoxycholicacidinvitro:G.Filaci,etal.;Int.J.Immunopharmacol.19,157(1997)
- IdentificationofaminoacidresiduesresponsIBLefordifferencesinsubstratespecificityandinhibitorsensitivitybetweentwohumanliverdihydrodioldehydrogenaseisoenzymesbysite-directedmutagenesis:K.Matsuura,etal.;Biochem.J.323,61(1997)
- Identificationofanuclearreceptorforbileacids:M.Makishima,etal.;Science284,1362(1999)
- Bileacids:naturalligandsforanorphannuclearreceptor:D.J.Parks,etal.;Science284,1365(1999)(Review)
- AnaturalproductthatlowerscholesterolasananatagoNISTligandforFXR:N.L.Urizar,etal.;Science296,1703(2002)
- Effectofchenodeoxycholicacidon11beta-hydroxysteroiddehydrogenaseinvarioustargettissues:D.J.Morris,etal.;Metabolism53,811(2004)
- TheFarnesoidXReceptor-AMolecularLinkBetweenBileAcidandLipidandGlucoseMetabolism:T.Claudel,etal.;Hepatology48,1632(2008)(Review)
- FarnesoidXreceptorantagonizesnuclearfactorkappaBinhepaticinflammatoryresponse:Y.D.Wang,etal.;Hepatology48,1632(2008)(Review)
- Bileacidsmodulateglucocorticoidmetabolismandthehypothalamic-pituitary-adrenalaxisinobstructivejaundice:A.D.McNeilly,etal.;J.Hepatol.52,705(2010)
- Effectsofbileacidsonexpressionofinterleukin-6andcellviabilityinQBC939cellline:J.Wang,etal.;ZhonghuaWaiKeZaZhi.48,919(2010)
- Fastingplasmachenodeoxycholicacidandcholicacidconcentrationsareinverselycorrelatedwithinsulinsensitivityinadults:B.Cariou,etal.;Nutrition&Metabolism8,48(2011)
- Deoxycholicandchenodeoxycholicbileacidsinduceapoptosisviaoxidativestressinhumancolonadenocarcinomacells:J.I.Barrasa,etal.;Apoptosis16,1054(2011)
- FarnesoidXreceptoractivationbychenodeoxycholicacidinducesdetoxifyingenzymesthroughAMP-activatedproteinkinaseandextracellularsignal-regulatedkinase1/2-mediatedphosphorylationofCCAAT/enhancerbindingproteinβ:K.Noh,etal.;DrugMetab.Dispos.39,1451(2011)
- Substratespecificityandinhibitoranalysesofhumansteroid5β-reductase(AKR1D1):M.Chen,etal.;Steroids76,484(2011)
- Effectofchenodeoxycholicacidonfibrosis,inflammationandoxidativestressinkidneyinhigh-fructose-fedWistarrats:Z.Hu,etal.;KidneyBloodPressRes.36,85(2012)
- Directeffectofchenodeoxycholicacidondifferentiationofmouseembryonicstemcellsculturedunderfeeder-freecultureconditions:S.J.Park,etal.;Biomed.Res.Int.2013,375076(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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