Adipogen/Chelerythrine chloride/AG-CR1-0071-M025/25 mg
商品编号：
AG-CR1-0071-M025
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC36405;1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride |
| ProductType | Chemical |
| Properties | |
| Formula | C21H18ClNO4 |
| MW | 383.8 |
| MerckIndex | 14:2051 |
| CAS | 3895-92-9 |
| RTECS | FL9200000 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Yellowtodarkyellowsolid. |
| Solubility | SolubleinDMSO,ethanol,methanolorwater(2mg/mlwarm). |
| Identity | Determinedby1H-NMR. |
| InChiKey | WEEFNMFMNMASJY-UHFFFAOYSA-M |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeablepotentinhibitorofproteinkinaseC.Doesnotinhibittyrosineproteinkinases,cAMP-dependentproteinkinaseorcalcium/calmodulin-dependentproteinkinase[1,5].
- Antiplatelet,anti-inflammatory,antibacterialandantitumorcompound[1,2,9,12,15].
- Apoptosisinducerincancercellsinvitroandinvivo[3,9].
- ActivatesMAPKandJUNKsignalingpathways[4,8].
- AffectstranslocationofPKCfromcytosoltoplasmamembrane[6].
- Neuriteoutgrowthstimulator[7].
- InhibitsbindingofBclXLtoBak(IC50=1.5μM)orBadproteinsandstimulatesapoptosisinseveralcancercelllines[10,13].
- BlockshumanP2X7receptor[11].
- InducescellcyclearrestinG1phase[14].
- Specificcyclooxygenase-2inhibitor[15].
ProductReferences
- ChelerythrineisapotentandspecificinhibitorofproteinkinaseC:J.M.Herbert,etal.;BBRC172,993(1990)
- AntiplateleteffectsofchelerythrinechlorideisolatedfromZanthoxylumsimulans:F.N.Ko,etal.;Biochim.Biophys.Acta1052,360(1990)
- InductionofapoptoticDNAfragmentationandcelldeathinHL-60humanpromyelocyticleukemiacellsbypharmacologicalinhibitorsofproteinkinaseC:W.D.Jarvis,etal.;CancerRes.54,1707(1994)
- Roleofc-juninhumanmyeloidleukemiacellapoptosisinducedbypharmacologicalinhibitorsofproteinkinaseC:A.J.Freemerman,etal.;Mol.Pharmacol.49,788(1996)
- Angolineandchelerythrine,benzophenanthridinealkaloidsthatdonotinhibitproteinkinaseC:S.K.Lee,etal.;J.Biol.Chem.273,19829(1998)
- InhibitionofproteinkinaseCtranslocationfromcytosoltomembranebychelerythrine:M.D.Chao,etal.;PlantaMed.64,662(1998)
- AxonaltransportisinhibitedbyaproteinkinaseCinhibitorinculturedisolatedmousedorsalrootganglioncells:H.Hiruma,etal.;Brain.Res.826,135(1999)
- Activationofp38andc-JunN-terminalkinasepathwaysandinductionofapoptosisbychelerythrinedonotrequireinhibitionofproteinkinaseC:R.Yu,etal.;J.Biol.Chem.275,9612(2000)
- InvitroandinvivoactivityofproteinkinaseCinhibitorchelerythrinechlorideinducestumorcelltoxicityandgrowthdelayinvivo:S.J.Chmura,etal.;Clin.CancerRes.6,737(2000)
- IdentificationofchelerythrineasaninhibitorofBclXLfunction:S.L.Chan,etal.;J.Biol.Chem.278,20453(2003)
- ChelerythrineandotherbenzophenanthridinealkaloidsblockthehumanP2X7receptor:A.N.Shemon,etal.;Br.J.Pharmacol.142,1015(2004)
- Theeffectofchelerythrineoncellgrowth,apoptosis,andcellcycleinhumannormalandcancercellsincomparisonwithsanguinarine:J.Malikova,etal.;CellBiol.Toxicol.22,439(2006)
- ChelerythrineinducesapoptosisthroughaBax/Bak-independentmitochondrialmechanism:K.F.Wan,etal.;J.Biol.Chem.283,8423(2008)
- ChelerythrineanddihydRochelerythrineinduceG1phasearrestandbimodalcelldeathinhumanleukemiaHL-60cells:J.Vrba,etal.;Toxicol.InVitro.22,1008(2008)
- Effectsofchelerythrine,aspecificinhibitorofcyclooxygenase-2,onacuteinflammationinmice:X.F.Niu,etal.;Fitoterapia82,620(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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