Adipogen/Chelerythrine chloride/AG-CR1-0071-M005/5 mg
商品编号：
AG-CR1-0071-M005
品牌：
Adipogen Inc
市场价：
¥1300.00
美元价：
780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | NSC 36405; 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
| Product Type | Chemical |
| Properties | |
| Formula | C21H18ClNO4 |
| MW | 383.8 |
| Merck Index | 14: 2051 |
| CAS | 3895-92-9 |
| RTECS | FL9200000 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Yellow to dark yellow solid. |
| Solubility | Soluble in DMSO, ethanol, methanol or water (2mg/ml warm). |
| Identity | Determined by 1H-NMR. |
| InChi Key | WEEFNMFMNMASJY-UHFFFAOYSA-M |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase [1, 5].
- Antiplatelet, anti-inflammatory, antibacterial and antitumor compound [1, 2, 9, 12, 15].
- Apoptosis inducer in cancer cells in vitro and in vivo [3, 9].
- Activates MAPK and JUNK signaling pathways [4, 8].
- Affects translocation of PKC from cytosol to plasma membrane [6].
- Neurite outgrowth stimulator [7].
- Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis in several cancer cell lines [10, 13].
- Blocks human P2X7 receptor [11].
- Induces cell cycle arrest in G1 phase [14].
- Specific cyclooxygenase-2 inhibitor [15].
Product References
- Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990)
- Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990)
- Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994)
- Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C: A.J. Freemerman, et al.; Mol. Pharmacol. 49, 788 (1996)
- Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C: S.K. Lee, et al.; J. Biol. Chem. 273, 19829 (1998)
- Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine: M.D. Chao, et al.; Planta Med. 64, 662 (1998)
- Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells: H. Hiruma, et al.; Brain. Res. 826, 135 (1999)
- Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C: R. Yu, et al.; J. Biol. Chem. 275, 9612 (2000)
- In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo: S.J. Chmura, et al.; Clin. Cancer Res. 6, 737 (2000)
- Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003)
- Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor: A.N. Shemon, et al.; Br. J. Pharmacol. 142, 1015 (2004)
- The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006)
- Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism: K.F. Wan, et al.; J. Biol. Chem. 283, 8423 (2008)
- Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells: J. Vrba, et al.; Toxicol. In Vitro. 22, 1008 (2008)
- Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice: X.F. Niu, et al.; Fitoterapia 82, 620 (2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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