Adipogen/cGAMP . disodium salt/AG-CR1-3588-C100/100 µg
商品编号：
AG-CR1-3588-C100
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | cyclic(adenosinemonophosphate-guanosinemonophosphate);cyclicGMP-AMP;c-(GpAp);c-(ApGp);3",3"-cGAMP |
| ProductType | Chemical |
| Properties | |
| Formula | C20H24N10O13P2.2Na |
| MW | 674.4.46.0 |
| CAS | 849214-04-6(freeacid) |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Crystallinesolid. |
| Solubility | Solubleinwater. |
| Reconstitution | Usesterile |
| InChiKey | MFPHQIYDBUVTRL-HBMYJXICSA-L |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto6monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentSTINGligand[2-8].
- SecondmessengerinhumanandmousecellsthattriggersinterferonproductioninresponsetocytosolicDNA[2-4].
- BindingtoSTINGleadstoactivationofIRF3(IFNregulatoryfactor3)andtheinductionofinterferon-β[3-6].
- Firstcyclicnucleotideinmetazoa[4].
- Playsaroleinbacterialchemotaxisandcolonization[1].
ProductReferences
- Coordinatedregulationofaccessorygeneticelementsproducescyclicdi-nucleotidesforV.choleraevirulence:B.W.Davies,etal.;Cell149,358(2012)
- CyclicGMP-AMPisanendogenoussecondmessengerininnateimmunesignalingbycytosolicDNA:J.Wu,etal.;Science339,826(2013)
- CyclicGMP-AMPsynthaseisacytosolicDNAsensorthatactivatesthetypeIinterferonpathway:L.Sun,etal.;Science339,786(2013)
- Cyclic[G(2",5")pA(3",5")p]isthemetazoansecondmessengerproducedbyDNA-activatedcyclicGMP-AMPsynthase:P.Gao,etal.;Cell153,1094(2013)
- TheinnateimmuneDNAsensorcGASproducesanoncanonicalcyclicdinucleotidethatactivateshumanSTING:E.J.Diner,etal.;CellRep.3,1355(2013)
- cGASproducesa2"-5"-linkedcyclicdinucleotidesecondmessengerthatactivatesSTING:A.Ablasser,etal.;Nature498,380(2013)
- StructuralmechanismofcytosolicDNAsensingbycGAS:F.Civril,etal.;Nature498,332(2013)
- CyclicGMP-AMPContainingMixedPhosphodiesterLinkagesIsAnEndogenousHigh-AffinityLigandforSTING:X.Zhang,etal.;Mol.Cell51,226(2013)
- ThecGAS-STINGPathwayforDNASensing:T.S.Xiao&K.A.Fitzgerald;Mol.Cell51,135(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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