Adipogen/Cerulenin/AG-CN2-0513-M005/5 mg
商品编号：
AG-CN2-0513-M005
品牌：
Adipogen Inc
市场价：
¥1700.00
美元价：
1020.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2R,3S-Epoxy-4-oxo-7,10-dodecADIenamide;Helicocerin |
| ProductType | Chemical |
| Properties | |
| Formula | C12H17NO3 |
| MW | 223.3 |
| CAS | 17397-89-6 |
| RTECS | JR1670000 |
| Source/HostChemicals | IsolatedfromCephalosporiumcaerulens. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(25mg/ml),ethanol(20mg/ml)orDMF(25mg/ml). |
| OtherProductData | StockSolution:PriortoperformingBIOLOGicalexperimentsthestocksolutionshouldbefurtherdilutedintowaterorotheraqueousbufferstoensurethattheresidualamountofDMSO/ethanolisinsignificant,sinceDMSOandethanolmayhavephysiologicaleffectsathighconcentrations. |
| InChiKey | GVEZIHKRYBHEFX-NQQPLRFYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. Protectfrommoistureandoxygen. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
- Antibioticandantifungalcompound.Inhibitorofbacterialfattyacidsynthesis(inhibitsFabH,FabBandFabFcondensationenzymes).
- IrreversIBLefattyacidsynthase(FAS)inhibitor.Inhibitssterolandfattyacidbiosynthesis.Infattyacidsynthesis,reportedtobindinequimolarratiotoβ-keto-acyl-ACPsynthase,thusinhibitingproteinacylation.Insterolsynthesis,inhibitsHMG-CoAsynthetaseactivity.
- Palmitoylation(apost-translationallipidation)inhibitor.
- Anticanceragent.Apoptosisinducerintumorcelllines,withupregulatedexpressionandactivityoffattyacidsynthase(FAS).ShowntoinduceapoptosisviadisruptionoftheinteractionbetweenAIFandHexokinaseII(HKII).
- Necroptosisinhibitorbyblockingverylong-chainfattyacids(VLCFA)synthesisandaccumulation,whichisimportantintheprocessofnecroptosis(RIP1-dependentcelldeath).
- Alsoleadstoprofoundweightlossandfeedinginhibitioninbothhigh-fatdietwildtypeobeseandleptin-deficientob/obmice.
ProductReferences
- Studiesoncerulenin,3.Isolationandphysico-chemicalpropertiesofcerulenin:Y.Sato,etal.;J.Antibiot.(Tokyo)200,344(1967)
- Inhibitionoffattyacidsynthetasesbytheantibioticcerulenin:D.Vance,etal.;Biochem.Biophys.Res.Commun.48,649(1972)
- Theantibioticcerulenin,anoveltoolforbiochemistryasaninhibitoroffattyacidsynthesis:S.Omura;Bacteriol.Rev.40,681(1976)(Review)
- Ceruleninisapotentinhibitorofantigenprocessingbyantigen-presentingcells:L.D.Falo,etal.;J.Immunol.139,3918(1987)
- Modulationofinsulinsecretionfromnormalratisletsbyinhibitorsofthepost-translationalmodificationsofGTP-bindingproteins:S.A.Metz,etal.;Biochem.J.295,31(1993)
- Inhibitoryeffectsofceruleninonproteinpalmitoylationandinsulininternalizationinratadipocytes:A.L.Jochen,etal.;Biochim.Biophys.Acta1259,65(1995)
- Reducedfoodintakeandbodyweightinmicetreatedwithfattyacidsynthaseinhibitors:T.M.Loftus,etal.;Science288,2379(2000)
- Cerulenin,aninhibitorofproteinacylation,selectivelyattenuatesnutrientstimulationofinsulinrelease:astudyinratpancreaticislets:H.Yajima,etal.;Diabetes49,712(2000)
- Ceruleninmimicseffectsofleptinonmetabolicrate,foodintake,andbodyweightindependentofthemelanocortinsystem,butunlikeleptin,ceruleninfailstoblockneuroendocrineeffectsoffasting:H.Makimura,etal.;Diabetes50,733(2001)
- Keyroleofmitochondriaincerulenin-mediatedapoptosis:S.J.Heiligtag,etal.;CellDeathDiffer.9,1017(2002)
- FattyacidsynthaseinhibitorsceruleninandC75retardgrowthandinducecaspase-dependentapoptosisinhumanmelanomaA-375cells:T.S.Ho,etal.;Biomed.Pharmacother.61,578(2007)
- Fattyacidsynthaseinhibitorceruleninsuppresseslivermetastasisofcoloncancerinmice:S.Murata,etal.;CancerSci.101,1861(2010)
- Cerulenin-inducedapoptosisismediatedbydisruptingtheinteractionbetweenAIFandhexokinaseII:N.Y.Jeong&Y.H.Yoo;Int.J.Oncol.40,1949(2012)
- Verylongchainfattyacidsarefunctionallyinvolvedinnecroptosis:L.R.Parisi,etal.;CellChem.Biol.(epubaheadofPrint)(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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