Adipogen/Celastrol/AG-CN2-0460-M050/50 mg
商品编号：
AG-CN2-0460-M050
品牌：
Adipogen Inc
市场价：
¥8800.00
美元价：
5280.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Tripterine;NSC70931 |
| ProductType | Chemical |
| Properties | |
| Formula | C29H38O4 |
| MW | 450.6 |
| MerckIndex | 14:10370 |
| CAS | 34157-83-0 |
| RTECS | YJ7900000 |
| Source/HostChemicals | IsolatedfromTripterygiumwilfordii. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Redsolid. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide.Insolubleinwater. |
| InChiKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anti-obesityagent.Potentleptinsensitizer.
- Antioxidant.
- Potentlipidperoxidationinhibitor.
- NADPHoxidases(NOX1,2,4and5)inhibitor.
- Anti-inflammatory.NF-κBinhibitor.
- HSP90inhibitorandHSP70inducer.
- Anticanceragent.Apoptosisandautophagyinducer.InhibitsPI3K/Aktsignalingpathways.
- Anti-metastaticandanti-angiogeniccompound.ReducesVEGFRexpressionandinhibitsHIF-1αpathway.
- TopoisomeraseIIinhibitor.
- 20Sproteasomechymotrypsin-likeactivityinhibitor.
- Potentialantiviralandanti-Alzheimer"sagent.
ProductReferences
- Thetriterpenecelastrolasaverypotentinhibitoroflipidperoxidationinmitochondria:H.Sassa,etal.;BBRC 172,890(1990)
- Celastrol,apotentantioxidantandanti-inflammatorydrug,asapossIBLetreatmentforAlzheimer"sdisease:A.C.Allison,etal.;Prog.Neuropsychopharmacol.Biol.Psychiatry25,1341(2001)
- AntiinflammatoryconstituentsofCelastrusorbiculatusinhibittheNF-kappaBactivationandNOproduction:H.Z.Jin,etal.;J.Nat.Prod.65,89(2002)
- ApoptosisinductioninHL-60cellsandinhibitionoftopoisomeraseIIbytriterpenecelastrol:M.Nagase,etal.;Biosci.Biotechnol.Biochem.67,1883(2003)
- InhibitionofNF-kappaBactivationthroughtargetingIkappaBkinasebycelastrol,aquinonemethidetriterpenoid:J.H.Lee,etal.;Biochem.Pharmacol.72,1311(2006)
- Celastrol,atriterpeneextractedfromtheChinese"ThunderofGodVine,"isapotentproteasomeinhibitorandsuppresseshumanprostatecancergrowthinnudemice:H.Yang,etal.;CancerRes.66,4758(2006)
- Celastrol,anovelHSP90inhibitor,depletesBcr-Ablandinducesapoptosisinimatinib-resistantchronicmyelogenousleukemiacellsharboringT315Imutation:Z.Lu,etal.;CancerLett.290,182(2010)
- Celastrol:MoleculartargetsofThunderGodVine:A.Salminen,etal.;BBRC394,439(2010)(Review)
- Celastrolactsasapotentantimetastaticagenttargetingbeta1integrinandinhibitingcell-extracellularmatrixadhesion,inpartviathep38mitogen-activatedproteinkinasepathway:H.Zhu,etal.;J.Pharmacol.Exp.Ther.334,489(2010)
- InhibitoryactionofCelastrolonhypoxia-mediatedangiogenesisandmetastasisviatheHIF-1αpathway:L.Huang,etal.;Int.J.Mol.Med.27,407(2011)
- NADPHoxidase(NOX)isoformsareinhibitedbycelastrolwithadualmodeofaction:V.Jaquet,etal.;Br.J.Pharmacol.164,507(2011)
- CelastrolinhibitsTat-mediatedhumanimmunodeficiencyvirus(HIV)transcriptionandreplication:V.Narayan,etal.;J.Mol.Biol.410,972(2011)
- Celastrolinhibitstumorcellproliferationandpromotesapoptosisthroughtheactivationofc-JunN-terminalkinaseandsuppressionofPI3K/Aktsignalingpathways:R.Kannaiyan,etal.;Apoptosis16,1028(2011)
- Celastrol,anNF-κBinhibitor,improvesinsulinresistanceandattenuatesrenalinjuryindb/dbmice:J.E.Kim,etal.;PLoSOne8,e62068(2013)
- InhibitionofC2C12myotubeatrophybyanovelHSP70inducer,celastrol,viaactivationofAkt1andERK1/2pathways:T.Gwag,etal.;Arch.Biochem.Biophys.537,21(2013)
- CelastrolinducesapoptosisandautophagyviatheROS/JNKsignalingpathwayinhumanosteosarcomacells:aninvitroandinvivostudy:H.Y.Li,etal.;CellDeathDis.6,e1604(2015)
- Treatmentofobesitywithcelastrol:J.Liu,etal.;Cell161,999(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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