Adipogen/CCT244747/SYN-1216-M010/10 mg
商品编号：
SYN-1216-M010
品牌：
Adipogen Inc
市场价：
¥6260.00
美元价：
3756.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (R)-3-((1-(Dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile |
| ProductType | Chemical |
| Properties | |
| Formula | C20H24N8O2 |
| MW | 408.5 |
| CAS | 1404095-34-6 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:CHK1|KinaseGroup:CAMK|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | IENLGMOXAQMNEH-CYBMUJFWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
CCT244747isanovel,potent,highlyselective,orallyactive,ATPcompetitiveCHK1inhibitor.CCT244747caninhibitcellularCHK1activitywithanIC50of29-170nM.Inmultipletumourcellmodels,thishastheeffectofsignificantlyenhancingthecytotoxicityofseveralanticancerdrugs(suchasgemcitabineandirinotecan)andabrogatingdrug-inducedSandG2arrest.
ProductReferences
- Discoveryof3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrilesasselective,orallybioavailableCHK1inhibitors:M.Lainchbury,etal.;J.Med.Chem.55,10229(2012)
- CCT244747isanovelpotentandselectiveCHK1inhibitorwithoralefficacyaloneandincombinationwithgenotoxicanticancerdrugs:M.I.Walton,etal.;Clin.CancerRes.18,5650(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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