Adipogen/Carboplatin/AG-CR1-3591-M250/250 mg
商品编号：
AG-CR1-3591-M250
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | cis-Diammine(cyclobutane-1,1-dicarboxylate-O,O")platinum(II);NSC201345;NSC241240;JM-8;Paraplatin;CBDca |
| ProductType | Chemical |
| Properties | |
| Formula | C6H12N2O4Pt |
| MW | 371.3 |
| MerckIndex | 14:1822 |
| CAS | 41575-94-4 |
| RTECS | TP2300000 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | YAYRGNWWLMLWJE-UHFFFAOYSA-L |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentplatinum-basedantineoplasticagent.Analogofcisplatin(Prod.No.AG-CR1-3590)withreducednephrotoxicityandhigherstability.
- Antitumoragent.
- Formsinter-andintrastrandDNAadducts/crosslinks,consequentlyblockingDNAreplicationandtranscriptionandinducingcelldeath.
- Interfereswithcelldivisionbymitosis.ThedamagedDNAelicitsDNArepairmechanisms,whichinturnactivateapoptosiswhenrepairisimpossIBLe.
- Apoptosisinducer.
- EnhancesrADIation-inducedsingle-strandDNAbreakage.
ProductReferences
- Pharmacokineticsofcis-diammine-1,1-cyclobutanedicarboxylateplatinum(II)inpatientswithnormalandimpairedrenalfunction:S.J.Harland,etal.;CancerRes.44,1693(1984)
- Carboplatin:averyactivenewcisplatinanaloginthetreatmentofsmallcelllungcancer:I.E.Smith,etal.;CancerTreatRep.69,43(1985)
- Carboplatin(JM8)asasingleagentandincombinationinthetreatmentofsmallcelllungcancer:I.E.Smith&B.D.Evans;CancerTreatRev.12(Suppl.A),73(1985)
- Carboplatinenhancestheproductionandpersistenceofradiation-inducedDNAsingle-strandbreaks:L.X.Yang,etal.;RadiationRes.143,302(1995)
- IncreasedDNA-bindingactivityofcis-1,1-cyclobutanedicarboxylatodiammineplatinum(II)(carboplatin)inthepresenceofnucleophilesandhumanbreastcancerMCF-7cellcytoplasmicextracts:activationtheoryrevisited:G.Natarajan,etal.;Biochem.Pharmacol.58,1625(1999)
- MechanismsofreactionofL-methioninewithcarboplatinandoxaliplatinindifferentmedia:acomparisonwithcisplatin:O.Heudi,etal.;Biopharm.DrugDispos.20,107(1999)
- Whatisthe"best"platinum:cisplatin,carboplatin,oroxaliplatin?J.Lokich;CancerInvest.19,756(2001)
- Newcluesforplatinumantitumorchemistry:KineticallycontrolledmetalbindingtoDNA:J.Reedijk;PNAS100,3611(2003)
- Highaccumulationofplatinum-DNAadductsinstrialmarginalcellsofthecochleaisanearlyeventincisplatinbutnotcarboplatinototoxicity:J.P.Thomas,etal.;Mol.Pharmacol.70,23(2006)
- p53regulatesERKactivationincarboplatininducedapoptosisincervicalcarcinoma:Anoveltargetofp53inapoptosis:S.Singh,etal.;FEBSLett.581,289(2007)
- Inhibitionoftranscriptionbyplatinumantitumorcompounds:R.C.Todd&S.J.Lippard;Metallomics1,280(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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