Adipogen/Calphostin C/AG-CN2-0430-C100/100 µg
商品编号：
AG-CN2-0430-C100
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UCN1028C;PKF115-584;Cal-C |
| ProductType | Chemical |
| Properties | |
| Formula | C44H38O14 |
| MW | 790.8 |
| CAS | 121263-19-2 |
| RTECS | FF7380000 |
| Source/HostChemicals | IsolatedfromCladosporiumcladosporioidessp. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Darkredtobrownsolid. |
| Solubility | Solubleinethanol,methanol,DMSOordimethylformamide.Poorlysolubleinwater. |
| InChiKey | SRJYZPCBWDVSGO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandhighlyspecificcellpermeableproteinkinaseC(PKC)inhibitor[1].TheinhibitionofPKCislight-dependent.
- PKA,PKG,DAGkinase,phospholipaseD1andD2,myosinlightchainkinaseandc-Srcinhibitor.
- Anticancercompound.Inhibitscellproliferationandstronglyinducesapoptosisinvitro.
- InducerofendoplasmicreticulumER-stress.
- ShowntodirectlyandpotentlyblockL-typeCachannels.
- CalphostinCspecificallyinhibitscontraction-stimulatedglucosetransportbutnotinsulin-stimulatedglucosetransportinskeletalmuscle.
- Wnt/β-catenin/lef-1signalinginhibitor.β-catenin/TCFantagoNIST.InhibitsWnt-activatedgenesinadose-dependentfashion
ProductReferences
- Calphostins(UCN-1028),novelandspecificinhibitorsofproteinkinaseC.I.Fermentation,isolation,physico-chemicalpropertiesandBIOLOGicalactivities:E.Kobayashi,etal.;J.Antibiot.(Tokyo)42,1470(1989)
- Calphostins,novelandspecificinhibitorsofproteinkinaseC.II.Chemicalstructures:T.Iida,etal.;J.Antibiot.(Tokyo).42,1475(1989)
- Useandspecificityofstaurosporine,UCN-01,andcalphostinCasproteinkinaseinhibitors:T.Tamaoki,etal.;MethodsEnzymol.201,340(1991)
- InhibitionofproteinkinaseCbycalphostinCislight-dependent:R.F.Burns,etal.;BBRC176,288(1991)
- CalphostinC,aspecificproteinkinaseCinhibitor,activateshumanneutrophils:effectonphospholipaseA2andaggregation:S.Svetlov&S.Nigam;Biochim.Biophys.Acta1177,75(1993)
- InhibitionofdiacylglycerolkinasebytheantitumoragentcalphostinC.EvidenceforsimilaritybetweentheactivesiteofdiacylglycerolkinaseandtheregulatorysiteofproteinkinaseC:C.Redman,etal.;Biochem.Pharmacol.50,235(1995)
- CalphostinC,awidelyusedproteinkinaseCinhibitor,directlyandpotentlyblocksL-typeCachannels:H.C.Hartzell&A.Rinderknecht;Am.J.Physiol.270,C1293(1996)
- CalphostinCsynergisticallyinducesapoptosiswithVP-16inlymphomacellswhichexpressabundantphosphorylatedBcl-2protein:M.Murata,etal.;Cell.Mol.LifeSci.53,737(1997)
- CalphostinCinducesselectivedisassemblyoftheGolgicomplexbyaproteinkinaseC-independentmechanism:M.Alonso,etal.;Eur.J.CellBiol.76,93(1998)
- GrowthinhibitioninducedbyRo31-8220andcalphostinCinhumanglioblastomacelllinesisassociatedwithapoptosisandinhibitionofCDC2kinase:MBegemann,etal.;AnticancerRes.18,3139(1998)
- CalphostinCtriggerscalcium-dependentapoptosisinhumanacutelymphoblasticleukemiacells:D.M.Zhu,etal.;Clin.CancerRes.4,2967(1998)
- CalphostinCisaninhibitorofcontraction,butnotinsulin-stimulatedglucosetransport,inskeletalmuscle:J.Ihlemann,etal.;ActaPhysiol.Scand.167,69(1999)
- PharmacokineticfeaturesandmetabolismofcalphostinC,anaturallyoccurringperylenequinonewithantileukemicactivity:C.L.Chen,etal.;Pharm.Res.16,1003(1999)
- PotentdirectinhibitionofmammalianphospholipaseDisoenzymesbycalphostin-c:V.A.Sciorra,etal.;Biochemistry40,2640(2001)
- CalphostinCasarapidandstronginducerofapoptosisinhumancoronaryarterysmoothmusclecells:K.D.Krueger,etal.;Int.Immunopharmacol.13,1751(2003)
- Calphostin-CinductionofvascularsmoothmusclecellapoptosisproceedsthroughphospholipaseDandmicrotubuleinhibition:X.L.Zheng,etal.;J.Biol.Chem.279,7112(2004)
- Small-moleculeantagonistsoftheoncogenicTcf/beta-cateninproteincomplex:M.Lepourcelet,etal.;CancerCell.5,91(2004)
- Golgicomplexdisassemblycausedbylight-activatedcalphostinCinvolvesMAPKandPKA:J.A.Morgado-Diaz,etal.;TissueCell39,161(2007)
- KillingofcancercellsbythephotoactivatableproteinkinaseCinhibitor,calphostinC,involvesinductionofendoplasmicreticulumstress:A.Kaul&W.AMaltese;Neoplasia11,823(2009)
- SmallmoleculeinhibitorsofWnt/beta-catenin/lef-1signalinginducesapoptosisinchroniclymphocyticleukemiacellsinvitroandinvivo:R.K.Gandhirajan,etal.;Neoplasia12,326(2010)
- Investigationof3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-dionesassmallmoleculeantagonistsofβ-catenin/TCFtranscription:J.Zeller,etal.;Bioorg.Med.Chem.Lett. 23,5814(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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