Adipogen/C646/AG-CR1-3508-M001/1 mg
商品编号：
AG-CR1-3508-M001
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C24H19N3O6 |
| MW | 445.4 |
| CAS | 328968-36-1 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Redsolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR.MixtureofisomersE/Z~4:1. |
| InChiKey | HEKJYZZSCQBJGB-XDHOZWIPSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- ReversIBLecellpermeablep300/CBPhistoneacetyltransferase(HAT)inhibitor.
- Specificinhibitiontop300(86%)comparedtoN-acetyltransferase,PCAF,GCN5,Rtt109,SasorMOZhistoneacetyltransferases(<10%).
- Cellgrowthinhibitorinmelanomaandnon-small-cell-lung(NSCL)humancancercelllines.
ProductReferences
- Virtualligandscreeningofthep300/CBPhistoneacetyltransferase:identificationofaselectivesmallmoleculeinhibitor:E.M.Bowers,etal.;Chem.Biol.17,471(2010)
- HATTrick:p300,SmallMolecule,Inhibitor:M.Ott&E.Verdin;Chem.Biol.17,417(2010)
- Butyrategreatlyenhancesderivationofhumaninducedpluripotentstemcellsbypromotingepigeneticsremodelingandtheexpressionofpluripotency-associatedgenes:P.Mali,etal.;StemCells28,713(2010)
- Dynamicacetylationofalllysine-4trimethylatedhistoneH3isevolutionarilyconservedandmediatedbyp300/CBP:N.T.Crump,etal.;PNAS108,7814(2011)
- ParadoxicalEnhancementofFearExtinctionMemoryandSynapticPlasticitybyInhibitionoftheHistoneAcetyltransferasep300:R.Marek,etal.;J.Neurosci.31,7486(2011)
- Inhibitionoftheacetyltransferasesp300andCBPrevealsatargetablefunctionforp300inthesurvivalandinvasionpathwaysofprostatecancercelllines:F.R.Santer,etal.;Mol.CancerTher.10,1644(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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