Adipogen/Butyrolactone I/BVT-0448-C200/200 µg
商品编号：
BVT-0448-C200
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C24H24O7 |
| MW | 424.5 |
| CAS | 87414-49-1 |
| Source/HostChemicals | IsolatedfromAspergillusterreus. |
| PurityChemicals | ≥98%(HPLC,NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,methanol,ethanoloracetone. |
| Identity | Determinedby1H-NMR. |
| InChiKey | NGOLMNWQNHWEKU-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potentandselectivecyclin-dependentkinaseCDK-1(CDC2),-2and-5inhibitor[1-4,9,10].
- Apoptosisinducer[6,7,9].
- Antitumoragent[5,9].
- InhibitscellcycleprogressionattheG1/SandG2/Mtransitions[8].
- ShowntopreventthephosphorylationofretinoblastomaproteinandH1histone[2,10].
- ImportantprobeforunderstandingthecellularrolesofCDKs[4].
- Inhibitorofα-glucosidases[12].
- Maturationinhibitorofsheepoocytes[11].
ProductReferences
- ButyrolactoneI,aselectiveinhibitorofcdk2andcdc2kinase:M.Kitagawa,etal.;Oncogene8,2425(1993)
- Acyclin-dependentkinaseinhibitor,butyrolactoneI,inhibitsphosphorylationofRBproteinandcellcycleprogression:M.Kitagawa,etal.;Oncogene9,2549(1994)
- Evidenceforcdk5asamajoractivityphosphorylatingtauproteininporcinebrainextract:T.Hosoi,etal.;J.Biochem.117,741(1995)
- Chemicalinhibitorsofcyclin-dependentkinases:L.Meijer;Prog.CellCycleRes.1,351(1995)(Review)
- AntitumoreffectsofbutyrolactoneI,aselectivecdc2kinaseinhibitor,onhumanlungcancercelllines:K.Nishio,etal.;AnticancerRes.16,3387(1996)
- Transcriptionalactivationofthecdc2geneisassociatedwithFas-inducedapoptosisofhumanhematopoieticcells:Y.Furukawa,etal.;J.Biol.Chem.271,28469(1996)
- Anexogenouscdkinhibitor,butyrolactone-I,inducesapoptosiswithincreasedBax/Bcl-2ratioinp53-mutatedpancreaticcancercells:M.Wada,etal.;AnticancerRes.18,2559(1998)
- ButyrolactoneIinducescyclinB1andcausesG2/Marrestandskippingofmitosisinhumanprostatecelllines:M.Suzuki,etal.;CancerLett.138,121(1999)
- InvolvementofCdk5/p25indigoxin-triggeredprostatecancercellapoptosis:H.Lin,etal.;J.Biol.Chem.279,29302(2004)
- RegulationofmitoticfunctionofChk1throughphosphorylationatnovelsitesbycyclin-dependentkinase1(Cdk1):T.Shiromizu,etal.;GenesCells11,477(2006)
- Butyrolactone-IreversIBLyinhibitsbutdoesnotimprovethematurationandsubsequentdevelopmentofsheepoocytesinvitro:L.Lu,etal.;J.AnimalVet.Adv.12,17(2013)
- Effectonα-glucosidaseinhibitionandantioxidantactivitiesofbutyrolactonederivativesfromAspergillusterreusMC751:R.Dewi,etal.;Med.Chem.Res.23,454(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
