Adipogen/BQ-123 . sodium salt/AG-CP3-0001-M005/5 mg
商品编号：
AG-CP3-0001-M005
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | EndothelinReceptorAAntagoNISTBQ-123; cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu).Na |
| ProductType | Chemical |
| Properties | |
| Formula | C31H42N6O7.Na |
| MW | 609.7.23.0 |
| CAS | 136655-57-7 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | Solubleinwater. |
| OtherProductData | Netpeptidecontent(AAA):73.1% |
| InChiKey | FLIKEIGEOXCRRG-DRBUQPBJSA-M |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandselectiveendothelinreceptorA(ETA)antagonist[1-3].
- SuppressestheET-1-induceddecreaseofLPLactivity[4].
- Showsprotectiveeffectsinischemicacuterenalfailure[5].
- Neuroprotective[6,10].
- Anti-hypertensive[7].
- InhibitsET-1receptorbindingandblocksCa2+mobilization,cellularcontractionandMAPkinaseactivation[8].
- Cardiovascularagent[9].
- Reducesmyocardialinfarctsizeandoxidantinjury[11].
- SelectedReviews[12,13].
ProductReferences
- InvitroBIOLOGicalprofileofahighlypotentnovelendothelin(ET)antagonistBQ-123selectivefortheETAreceptor:M.Ihara,etal.;J.Cardiovasc.Pharmacol.20,S11(1992)
- BQ-123,cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu),isanon-competitiveantagonistoftheactionsofendothelin-1inSK-N-MChumanneuroblastomacells:C.R.Hiley,etal.;BBRC184,504(1992)
- BiologicalprofilesofhighlypotentnovelendothelinantagonistsselectivefortheETAreceptor:M.Ihara,etal.;LifeSci.50,247(1992)
- Suppressiveeffectsoftheendothelinreceptor(ETA)antagonistBQ-123onET-1-inducedreductionoflipoproteinlipaseactivityin3T3-L1ADIpocytes:F.Ishida,etal.;Biochem.Pharmacol.44,1431(1992)
- Protectiveeffectofaselectiveendothelinreceptorantagonist,BQ-123,inischemicacuterenalfailureinrats:N.Mino,etal.;Eur.J.Pharmacol.221,77(1992)
- Peptidicendothelin-1receptorantagonist,BQ-123,andneuroprotection:G.Feuerstein,etal.;Peptides15,467(1994)
- BQ-123,aselectiveendothelinsubtypeA-receptorantagonist,lowersbloodpressureindifferentratmodelsofhypertension:S.A.Douglas,etal.;J.Hypertens.12,561(1994)
- InhibitoryeffectofBQ-123onendothelin-1-stimulatedmitogen-activatedproteinkinaseandcellgrowthofratvascularsmoothmusclecells:X.Guo,etal.;Hypertens.Res.19,23(1996)
- Inhibitionofmyocardialendothelinpathwayimproveslongtermsurvivalinheartfailure:S.Sakai,etal.;Nature384,353(1996)
- SimilarprotectiveeffectsofBQ-123anderythropoietinonsurvivalofneuralcellsandgenerationofneuronsuponhypoxicinjury:L.Danielyan,etal.;Eur.J.CellBiol.84,907(2005)
- Selectiveendothelina(ETA)receptorantagonist(BQ-123)reducesbothmyocardialinfarctsizeandoxidantinjury:R.Ozdemir,etal.;Toxicology219,142(2006)
- Endothelinreceptorantagonists:S.Motte,etal.;Pharmacol.Ther.110,386(2006)(Review)
- ETA-receptorantagonistsorallostericmodulators?:J.G.DeMey,etal.;TIPS32,345(2011)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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