Adipogen/Bosutinib/SYN-1025-M010/10 mg
商品编号：
SYN-1025-M010
品牌：
Adipogen Inc
市场价：
¥1520.00
美元价：
912.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | SKI-606 |
| Product Type | Chemical |
| Properties | |
| Formula | C26H29Cl2N5O3 |
| MW | 530.5 |
| CAS | 380843-75-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg l)="" in="" ethanol.=""> |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Src - Abl | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | UBPYILGKFZZVDX-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Bosutinib is a novel, dual Src/Abl inhibitor with IC(50) values of 1.2nM and 1nM, respectively.
Product References
- Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity: D.H. Boschelli, et. al.; J. Med. Chem. 44, 3965 (2001)
- SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice: J.M. Golas, et al.; Cancer Res. 63, 375 (2003)
- SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models: J.M. Golas, et al.; Cancer Res. 65, 5358 (2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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