Adipogen/Bortezomib/AG-CR1-3602-M005/5 mg
商品编号：
AG-CR1-3602-M005
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PS-341;LDP-341;MLM-341;MG-341;NSC-681239;ProteasomeInhibitor |
| ProductType | Chemical |
| Properties | |
| Formula | C19H25BN4O4 |
| MW | 384.2 |
| CAS | 179324-69-7 |
| RTECS | ED7771666 |
| PurityChemicals | ≥97%(NMR) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,ethanolormethanol.Slightlysolubleinwater. |
| InChiKey | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Highlypotent,selectiveandreversIBLecellpermeableinhibitoroftheproteasome.Inhibitsthechymotrypsin-likeandcaspase-likepeptidaseactivityoftheproteasome.
- Calpainandcathepsininhibitor.
- Autophagyactivator.
- Anticancercompound.Inhibitsproliferationandmigrationofseveraltumorcelllineswithnanomolarpotency.
- Apoptosisinducer.
ProductReferences
- Proteasomeinhibitors:anovelclassofpotentandeffectiveantitumoragents:J.Adams,etal.;CancerRes.59,2615(1999)
- DevelopmentoftheproteasomeinhibitorVelcade(Bortezomib):J.Adams&M.Kauffmann;CancerInvest.22,304(2004)
- BortezomibinhibitsPKR-likeendoplasmicreticulum(ER)kinaseandinducesapoptosisviaERstressinhumanpancreaticcancercells:S.T.Nawrocki,etal.;CancerRes.65,11510(2005)
- AnovelorallyactiveproteasomeinhibitorinducesapoptosisinmultiplemyelomacellswithmechanismsdistinctfromBortezomib:D.Chauhan,etal.;CancerCell8,407(2005)
- Importanceofthedifferentproteolyticsitesoftheproteasomeandtheefficacyofinhibitorsvarieswiththeproteinsubstrate:A.F.Kisselev,etal.;J.Biol.Chem.281,8582(2006)
- Bortezomibinteractionswithchemotherapyagentsinacuteleukemiainvitro:T.M.Horton,etal.;CancerChemother.Pharmacol.58,13(2006)
- Bortezomibasanantitumoragent:A.M.Roccaro,etal.;Curr.Pharm.Biotechnol.7,441(2006)(Review)
- Aggravatedendoplasmicreticulumstressasabasisforenhancedglioblastomacellkillingbybortezomibincombinationwithcelecoxiboritsnon-coxibanalogue,2,5-dimethyl-celecoxib:A.Kardosh,etal.;CancerRes.68,843(2008)
- ProteasomeinhibitorPS-341(bortezomib)inducescalpain-dependentIkappaB(alpha)degradation:C.Li,etal.;J.Biol.Chem.285,16096(2010)
- BortezomibsuppressesfunctionandsurvivalofplasmacytoiddendriticcellsbytargetingintracellulartraffickingofToll-likereceptorsandendoplasmicreticulumhomeostasis:M.Hirai,etal.;Blood117,500(2011)
- Bortezomib,aproteasomeinhibitor,attenuatesangiotensinII-inducedhypertensionandaorticremodelinginrats:S.Li,etal;PLoSOne8,e78564(2013)
- BortezomibinducesprotectiveautophagythroughAMP-activatedproteinkinaseactivationinculturedpancreaticandcolorectalcancercells:H.Min,etal.;CancerChemother.Pharmacol.74,167(2014)
- BortezomibisarapidmobilizerofhematopoieticstemcellsinmiceviamodulationoftheVCAM-1/VLA-4axis:A.GhobADI,etal.;Blood124,2752(2014)
- BortezomibinhibitsC2C12growthbyinducingcellcyclearrestandapoptosis:S.S.Xing,etal.;BBRC445,375(2014)
- BortezomibpreventsoncogenesisandbonemetastasisofprostatecancerbyinhibitingWWP1,Smurf1andSmurf2:Z.Wang,etal.;Int.J.Oncol.45,1469(2014)
- Efficientapoptosisandnecrosisinductionbyproteasomeinhibitor:bortezomibintheDLD-1humancoloncancercellline:R.Krętowski,etal.;Mol.CellBiochem.398,165(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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