Adipogen/Borrelidin/BVT-0098-M005/5 mg
商品编号：
BVT-0098-M005
品牌：
Adipogen Inc
市场价：
¥6400.00
美元价：
3840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Treponemycin;U78548;C2989 |
| ProductType | Chemical |
| Properties | |
| Formula | C28H43NO6 |
| MW | 489.6 |
| CAS | 7184-60-3 |
| RTECS | ED8750000 |
| Source/HostChemicals | IsolatedfromStreptomycessp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSOormethanol. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | OJCKRNPLOZHAOU-TVHKGLGPSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Macrolideantibiotic.
- Bacterial,protozoanandmammalianthreonyl-tRNAsynthetase(THrRS)inhibitor.
- Antiangiogenic(IC50=0.8nM)andanticanceragent.
- Inducesthecollapseofformedcapillarytubesinadose-dependentfashion.InHUVECs,thecapillarytubecollapsingactivityismediatedbytheactivationofcaspases-3and-8andinductionofapoptosis.
- BlockstheformationofspontaneouslungmetastasesofB16-BL6melanomacells.
- Cyclin-dependentkinase(CDK)inhibitor.
- Antiviral.
- Potentantimalarialagent(IC50=0.97nM).
- Inhibitorofpotatoscabdisease.
ProductReferences
- Isolationofvivomycinandborrelidin,twoantibioticswithanti-viralactivity,fromaspeciesofStreptomyces(C2989):M.Lumb,etal.;Nature206,263(1965)
- Geneticanalysisofmutationscausingborrelidinresistancebyoverproductionofthreonyl-transferribonucleicacidsynthetase:J.Frohler,etal.;J.Bacteriol.143,1135(1980)
- Increasedlevelsofthreonyl-tRNAsynthetaseinaborrelidin-resistantChinesehamsterovarycellline:J.S.Gantt,etal.;PNAS78,5367(1981)
- Chinesehamsterovarycellsresistanttoborrelidinoverproducethreonyl-tRNAsynthetase:S.C.GerkenandS.M.Arfin;J.Biol.Chem.259,9202(1984)
- IsolationofaCDNAcloneforhumanthreonyl-tRNAsynthetase:amplificationofthestructuralgeneinborrelidin-resistantcelllines:K.J.KontisandS.M.Arfin;Mol.Cell.Biol.9,1832(1989)
- Borrelidinisanangiogenesisinhibitor;disruptionofangiogeniccapillaryvesselsinarataortamatrixculturemodel:T.Wakabayashi,etal.;J.Antibiot.50,671(1997)
- Establishmentofaquantitativemousedorsalairsacmodelanditsapplicationtoevaluateanewangiogenesisinhibitor:Y.Funahashi,etal.;Oncol.Res.11,319(1999)
- Borrelidininhibitsacyclin-dependentkinase(CDK),Cdc28/Cln2,ofSaccharomycescerevisiae:E.Tsuchiya,etal.;J.Antibiot.54,84(2001)
- Anti-angiogenesiseffectsofborrelidinaremediatedthroughdistinctpathways:threonyl-tRNAsynthetaseandcaspasesareindependentlyinvolvedinsuppressionofproliferationandinductionofapoptosisinendothelialcells:T.Kawamura,etal.;J.Antibiot.56,709(2003)
- BorrelidininducesthetranscriptionofaminoacidbiosyntheticenzymesviaaGCN4-dependentpathway:E.L.Eastwood&S.E.Schaus;Bioorg.Med.Chem.Lett.13,2235(2003)
- Auniquehydrophobicclusterneartheactivesitecontributestodifferencesinborrelidininhibitionamongthreonyl-tRNAsynthetases:B.Ruan,etal.;J.Biol.Chem.280,571(2005)
- Borrelidin,apotentantimalarial:stage-specificinhibitionprofileofsynchronizedculturesofPlasmodiumfalciparum:A.Ishiyama,etal.;J.Antibiotics64,381(2011)
- Astudyontheeffectsofborrelidinoncardiovascularandintestinalsmoothmuscles:D.V.Bhikshapathi,etal.;Pharm.Lett.5,83(2013)
- Insightsintothepreclinicaltreatmentofblood-stagemalariabytheantibioticborrelidin:I.G.Azcarate,etal.;Br.J.Pharmacol.169,645(2013)
- Identificationofborrelidinbindingsiteonthreonyl-tRNAsynthetase:M.Li,etal;Biochem.Biophys.Res.Comm.451,485(2014)
- Analogsofnaturalaminoacyl-tRNAsynthetaseinhibitorsclearmalariainvivo:E.M.Novoa,etal.;PNAS(USA)111,E5508(2014)
- Borrelidinhaslimitedanti-cancereffectsinbcl-2overexpressingbreastcancerandleukemiacellsandrevealstoxicityinnon-malignantbreastepithelialcells:D.Gafiuc,etal.;J.Appl.Toxicol.34,1109(2014)
- Borrelidinormicroorganismwhichproducesitasinhibitorofpotatoscabdisease:Y.Kobayashi,etal.;Jap.KokaiTokkyoKohoJP2014224102(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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