Adipogen/BMS-309403/AG-CR1-3640-M025/25 mg
商品编号：
AG-CR1-3640-M025
品牌：
Adipogen Inc
市场价：
¥4900.00
美元价：
2940.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BMS309403;BMS309403;FABP4Inhibitor;2-[[2"-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1"-biphenyl]-3-yl]oxy]aceticacid |
| ProductType | Chemical |
| Properties | |
| Formula | C31H26N2O3 |
| MW | 474.6 |
| CAS | 300657-03-8 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(25mg/ml),ethanol(30mg/ml),dimethylformamide(30mg/ml)ormethanol.Almostinsolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | SJRVJRYZAQYCEE-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potentandselectivefattyacidbindingprotein4(FABP4;A-FABP;ALBP;ADIpocyteP2protein)inhibitorthatcompetitivelytargetsthefattyacid-bindingpocket(Ki=<2nM).InhibitsFABP3(muscle)andFABP5(epidermal)withloweraffinity(Ki=250nMand350nM,respectively).FABP4isanintracellularlipid-bindingproteinresponsIBLeforthetransportationoffattyacids.Itisexpressedprimarilyinadiposetissueandisassociatedwithinflammation,obesity,diabetesandcardiovasculardiseases.
- Glucoseuptakestimulator.Reducesbloodglucoselevelsandincreasesinsulinsensitivityinamousemodelofobesity.Protectsagainstthedevelopmentofinsulinresistanceassociatedwithgeneticordiet-inducedobesityinmice.
- Anti-atherosclerotic.Decreasesfattyaciduptakeinadipocytesinvitroandreducesatheroscleroticlesionareainamousemodelofatherosclerosis.
ProductReferences
- Potentandselectivebiphenylazoleinhibitorsofadipocytefattyacidbindingprotein(aFABP):R.Sulsky,etal.;Bioorg.Med.Chem.Lett.17,3511(2007)
- Treatmentofdiabetesandatherosclerosisbyinhibitingfatty-acid-bindingproteinaP2:M.Furuhashi,etal.;Nature447,959(2007)
- BMS309403stimulatesglucoseuptakeinmyotubesthroughactivationofAMP-activatedproteinkinase:W.Lin,etal.;PLoSOne7,e44570(2012)
- FABP4attenuatesPPARγandAdipogenesisandisinverselycorrelatedwithPPARγinadiposetissues:T.Garin-Shkolnik,etal.;Diabetes63,900(2014)
- FABP4inhibitionsuppressesPPARγactivityandVLDL-inducedfoamcellformationinIL-4-polarizedhumanmacrophages:M.Boss,etal.;Atherosclerosis240,424(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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