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Adipogen/Bisindolylmaleimide VIII . acetate/AG-CR1-0114-M001/1 mg
Adipogen/Bisindolylmaleimide VIII . acetate/AG-CR1-0114-M001/1 mg
商品编号：
AG-CR1-0114-M001
品牌：
Adipogen Inc
市场价：
¥900.00
美元价：
540.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ro31-7549;BIMVIII |
| ProductType | Chemical |
| Properties | |
| Formula | C24H22N4O2.CH3COOH |
| MW | 398.5.60.1 |
| CAS | 138516-31-1 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Redpowder. |
| Solubility | SolubleinDMSO,methanolorwater.Slightlysolubleinethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | VEOXVBTXROWDAH-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveproteinkinaseC(PKC)inhibitor[1-3].
- Inhibitsproliferationofculturedmouseepidermalkeratinocytes[4].
- EnhancesFas-andTRAIL-mediatedapoptosis[5,6].
- InhibitsTcell-mediatedautoimmunediseases[5].
- Inhibitsstimulationofinsulinsecretionbyglucose[8].
- Inhibitspanelofproteinkinases(e.g.GSK-3β,CDK2)[7].
ProductReferences
- RO31-8220andRO31-7549showimprovedselectivityforproteinkinaseCoverstaurosporineinmacrophages:P.Dieter&E.Fitzke;BBRC181,396(1991)
- Isoenzymespecificityofbisindolylmaleimides,selectiveinhibitorsofproteinkinaseC:S.E.Wilkinson,etal.;Biochem.J.294,335(1993)
- InhibitorsofproteinkinaseC.3.Potentandhighlyselectivebisindolylmaleimidesbyconformationalrestriction:R.A.Bit,etal.;J.Med.Chem.36,21(1993)
- EffectsoftheselectiveproteinkinaseCinhibitor,Ro31-7549,ontheproliferationofculturedmouseepidermalkeratinocytes:W.B.Bollag,etal.;J.Invest.Dermatol.100,240(1993)
- BisindolylmaleimideVIIIfacilitatesFas-mediatedapoptosisandinhibitsTcell-mediatedautoimmunediseases:T.Zhou,etal.;Nat.Med.5,42(1999)
- BisindolylmaleimideVIIIenhancesDR5-mediatedapoptosisthroughtheMKK4/JNK/p38kinaseandthemitochondrialpathways:T.Ohtsuka&T.Zhou;J.Biol.Chem.277,29294(2002)
- Proteome-wideidentificationofcellulartargetsaffectedbybisindolylmaleimide-typeproteinkinaseCinhibitors:D.Brehmer,etal.;Mol.CellProteomics3,490(2004)
- Differentsignalingpathwaysinvolvedinglucose-andcellswelling-inducedinsulinsecretionbyratpancreaticisletsinvitro:Z.Bacova,etal.;CellPhysiol.Biochem.16,59(2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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