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Adipogen/Bisindolylmaleimide IX . methanesulfonate/AG-CR1-0111-M001/1 mg
Adipogen/Bisindolylmaleimide IX . methanesulfonate/AG-CR1-0111-M001/1 mg
商品编号：
AG-CR1-0111-M001
品牌：
Adipogen Inc
市场价：
¥1100.00
美元价：
660.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ro31-8220;BIMIX |
| ProductType | Chemical |
| Properties | |
| Formula | C25H23N5O2S.CH4O3S |
| MW | 457.6.96.1 |
| CAS | 138489-18-6 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Redsolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | SAWVGDJBSPLRRB-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveandcellpermeableproteinkinaseC(PKC)inhibitor[1,2,3].
- Inhibitsthestimulationofinsulinsecretionbyglucose[4,11].
- InhibitsTcellactivation[5].
- Apoptosisinducer[6,8,9,10,13].
- Potentglycogensynthasekinase-3(GSK-3)inhibitor[7].
- Transcriptioninhibitor[9].
- InducesTNFreceptorfamily-mediatedcelldeath[10].
- Pim-1kinaseinhibitor[12].
- Antitumorcompound[13].
ProductReferences
- PotentselectiveinhibitorsofproteinkinaseC:P.D.Davis,etal.;FEBSLett.259,61(1989)
- RO31-8220andRO31-7549showimprovedselectivityforproteinkinaseCoverstaurosporineinmacrophages:P.Dieter&E.Fitzke;BBRC181,396(1991)
- Isoenzymespecificityofbisindolylmaleimides,selectiveinhibitorsofproteinkinaseC:S.E.Wilkinson,etal.;Biochem.J.294,335(1993)
- Inhibitionofglucose-stimulatedinsulinsecretionbyRo31-8220,aproteinkinaseCinhibitor:S.J.Persaud&P.M.Jones;Endocrine3,285(1995)
- RO31-8220,anovelproteinkinaseCinhibitor,inhibitsearlyandlateTcellactivationevents:L.Geiselhart,etal.;Transplantation61,1637(1996)
- InductionofapoptosisinglioblastomacellsbyinhibitionofproteinkinaseCanditsassociationwiththerapidaccumulationofp53andinductionoftheinsulin-likegrowthfactor-1-bindingprotein-3:L.Shen&R.I.Glazer;Biochem.Pharmacol.55,1711(1998)
- TheproteinkinaseCinhibitorsbisindolylmaleimideI(GF109203x)andIX(Ro31-8220)arepotentinhibitorsofglycogensynthasekinase-3activity:I.Hers,etal.;FEBSLett.460,433(1999)
- Thestaurosporineanalog,Ro-31-8220,inducesapoptosisindependentlyofitsabilitytoinhibitproteinkinaseC:Z.Han,etal.;CellDeathDiffer.7,521(2000)
- BisindolylmaleimideIXfacilitatestumornecrosisfactorreceptorfamily-mediatedcelldeathandactsasaninhibitoroftranscription:O.W.Rokhlin,etal.;J.Biol.Chem.277,33213(2002)
- BisindolylmaleimideIXInducesReversIBLeandTime-DependentTumorNecrosisFactorReceptorFamily-MediatedCaspaseActivationandCellDeath:O.W.Rokhlin&M.B.Cohen;CancerBiol.Ther.2,266(2003)
- ProteinkinaseC-independenteffectsofproteinkinaseD3inglucosetransportinL6myotubes:J.Chen,etal.;Mol.Pharmacol.67,152(2005)
- Pim-1ligand-boundstructuresrevealthemechanismofserine/threoninekinaseinhibitionbyLY294002:M.D.Jacobs,etal.;J.Biol.Chem.280,13728(2005)
- BisindolylmaleimideIXfacilitatesextrinsicandinitiatesintrinsicapoptosisinTNF-alpha-resistanthumancolonadenocarcinomaCOLO205cells:B.Pajak,etal.;Apoptosis13,509(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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