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Adipogen/Bisindolylmaleimide I . hydrochloride/AG-CR1-0110-M001/1 mg
Adipogen/Bisindolylmaleimide I . hydrochloride/AG-CR1-0110-M001/1 mg
商品编号：
AG-CR1-0110-M001
品牌：
Adipogen Inc
市场价：
¥1100.00
美元价：
660.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GF109203X;Gö6850;BIMI |
| ProductType | Chemical |
| Properties | |
| Formula | C25H24N4O2.HCl |
| MW | 412.5.36.5 |
| CAS | 176504-36-2 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Orangetoredpowder. |
| Solubility | SolubleinDMSOormethanol.Slightlysolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | XRAMWNCMYJHGGH-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeablekinaseinhibitorwithimprovedselectivityforproteinkinaseC(PKC)(Ki =10nM)[1].
- CompetitiveinhibitorfortheATP-bindingsiteofPKC[1].
- Anti-inflammatory[2].
- BindstoP-glycoprotein[3].
- Telomeraseactivityinhibitor[4].
- Potentglycogensynthasekinase-3(GSK-3)inhibitor[5].
- Necrosisinhibitor[6].
- BlockshERGpotassiumchannels[7-9].
- Promotesosteoblastogenesisinhumanmesenchymalstemcells[10].
ProductReferences
- ThebisindolylmaleimideGF109203XisapotentandselectiveinhibitorofproteinkinaseC:D.Toullec,etal.;J.Biol.Chem. 266,15771(1991)
- Anti-inflammatorypropertiesoftheproteinkinaseCinhibitor,3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dionemonohydrochloride(GF109203X)inthePMA-mouseearedemamodel:S.Kuchera,etal.;AgentsActions 39,C169(1993)
- EffectsoftheselectivebisindolylmaleimideproteinkinaseCinhibitorGF109203XonP-glycoprotein-mediatedmultidrugresistance:V.Gekeler,etal.;Br.J.Cancer 74,897(1996)
- InhibitionoftelomeraseactivitybyPKCinhibitorsinhumannasopharyngealcancercellsinculture:W.C.Ku,etal.;BBRC241,730(1997)
- TheproteinkinaseCinhibitorsbisindolylmaleimideI(GF109203x)andIX(Ro31-8220)arepotentinhibitorsofglycogensynthasekinase-3activity:I.Hers,etal.;FEBSLett.460,433(1999)
- BisindolylmaleimideIandVinhibitnecrosisinducedbyoxidativestressinavarietyofcellsincludingneurons:R.Asakai,etal.;Neurosci.Res.44,297(2002)
- DirectblockofhERGpotassiumchannelsbytheproteinkinaseCinhibitorbisindolylmaleimideI(GF109203X):D.Thomas,etal.;Cardiovasc.Res.64,467(2004)
- TheproteinkinaseCinhibitor,bisindolylmaleimide(I),inhibitsvoltage-dependentK+channelsincoronaryarterialsmoothmusclecells:W.S.Park,etal.;LifeSci.77,512(2005)
- EffectsofthePKCinhibitorschelerythrineandbisindolylmaleimideI(GF109203X)ondelayedrectifierK(+)currents:G.Harmati,etal.;NaunynSchmiedebergsArch.Pharmacol.383,141(2011)
- BisindolylmaleimideIenhancesosteogenicdifferentiation:F.Zhou,etal.;Prot.Cell3,311(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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