脂肪原/桦木脂素/AG-CN2-0476-G001/1 g
商品编号：
AG-CN2-0476-G001
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Betulinol;Trochol;NSC4644 |
| ProductType | Chemical |
| Properties | |
| Formula | C30H50O2 |
| MW | 442.7 |
| MerckIndex | 14:1198 |
| CAS | 473-98-3 |
| RTECS | OK5755000 |
| Source/HostChemicals | IsolatedfromBetulaceaefamilytreebark. |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,DMForethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | FVWJYYTZTCVBKE-ROUWMTJPSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SpecificSREBPs(sterolregulatoryelement-bindingproteins)inhibitor.InhibitsER-GolgitranslocationofSREBPsthroughbindingtoSCAPinanINSIG-dependentmanner.
- Improveshyperlipidemiaandinsulinresistanceandreducesatheroscleroticplaques.LowerscholesterollevelsthroughinhibitionofSREBP-2activation.ReducesweightgainandADIposetissuesizeinvivo.Increasesoxygenconsumptionandenergyexpenditure.IncreasesUCP1/2levelsinbrownadiposetissue(BAT)aftercoldstimulation.
- Anticancercompound.Apoptosisinducer.DNAtopoisomeraseIIinhibitor.
- Anti-inflammatorycompound.ShowntoinhibitLPS-inducedNOproductionthroughtheTLR4/NF-κBsignalingpathway.
- Antiviralcompound.
ProductReferences
- ScreeningoftriterpenoidsisolatedfromPhyllanthusflexuosusforDNAtopoisomeraseinhibitoryactivity:S.Wada,etal.;J.Nat.Prod.64,1545(2001)
- Thesynergisticeffectsofbetulinwithacycloviragainstherpessimplexviruses:Y.Gong,etal.;AntiviralRes.64,127(2004)
- InhibitionofSREBPbyasmallmolecule,betulin,improveshyperlipidemiaandinsulinresistanceandreducesatheroscleroticplaques:J.J.Tang,etal.;CellMetab.13,44(2011)
- Akeyregulatorofcholesterolhomoeostasis,SREBP-2,canbetargetedinprostatecancercellswithnaturalproducts:J.R.Krycer,etal.;Biochem.J.446,191(2012)
- TargetingSREBPsfortreatmentofthemetabolicsyndrome:S.M.Soyal,etal.;TrendsPharmacol.Sci.36,406(2015)
- Inductionofapoptoticcelldeathbybetulininmultidrug-resistanthumanrenalcarcinomacells:N.H.Yim,etal.;Oncol.Rep.34,1058(2015)
- Comprehensivereviewonbetulinasapotentanticanceragent:S.K.Krol,etal.;Biomed.Res.Int.2015(Review)
- Betulinderivativeseffectivelysuppressinflammationinvitroandinvivo:M.Laavola,etal.;J.Nat.Prod.79,274(2016)
- BetulinattenuateskidneyinjuryinsepticratsthroughinhibitingTLR4/NF-κBsignalingpathway:H.Zhao,etal.;LifeSci.144,185(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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