| Product Details | |
|---|---|
| Synonyms | Natural Yellow 18; Berberinium chloride; BBR; Umbellatine; Majarine; Thalsine |
| Product Type | Chemical |
| Properties | |
| Formula | C20H17NO4 . HCl |
| MW | 335.3 . 36.5 |
| CAS | 633-65-8 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | Yellow to orange powder. |
| Solubility | Soluble in DMSO or methanol. Slightly soluble in ethanol or water. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | VKJGBAJNNALVAV-UHFFFAOYSA-M |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.
(1) P.J. Kaboli, et al.; Eur. J. Pharmacol. 740, 584 (2014) | (2) L.M. Ortiz, et al.; Molecules 19, 12349 (2014) | (3) W.J. Ni, et al.; Eur. J. Pharmacol. 760, 103 (2015) | (4) C.J. Yu, et al.; J. Alzheimers Dis. 22, 257 (2010)
