Adipogen/BAY 58-2667 . hydrochloride/AG-CR1-3509-M001/1 mg
商品编号：
AG-CR1-3509-M001
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C36H39NO5.HCl.0.5H2O |
| MW | 565.6.36.5.9.0 |
| CAS | 646995-35-9 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | LLHMBJOVHATVSP-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Nitricoxide(NO)-andheme-independentsolubleguanylylcyclaseactivator.
- Showspotentcardiovasculareffects.Improvescardiopulmonaryhemodynamicsinpatientswithacutedecompensatedheartfailure.
- Exhibitspotentvasodilatorandantiplateletactivity.
- Anti-aggregatingagent.
ProductReferences
- NO-andhaem-independentactivationofsolubleguanylylcyclase:molecularbasisandcardiovascularimplicationsofanewpharmacologicalprinciple:J.P.Stasch,etal.;Br.J.Pharmacol.136,773(2002)
- Mechanismsofnitricoxideindependentactivationofsolubleguanylylcyclase:P.Schmidt,etal.;Eur.J.Pharmacol.468,167(2003)
- Nitricoxide-independentstimulationofsolubleguanylatecyclasewithBAY41-2272incardiovasculardisease:G.Boerrigter&JC.BurnettJr.;Cardiovasc.DrugRev.25,30(2007)(Review)
- Pharmacokinetics,pharmacodynamics,tolerability,andsafetyofthesolubleguanylatecyclaseactivatorcinaciguat(BAY58-2667)inhealthymalevolunteers:R.Frey,etal.;J.Clin.Pharmacol.48,1400(2008)
- BAY58-2667,anitricoxide-independentguanylylcyclaseactivator,pharmacologicallypost-conditionsrabbitandrathearts:T.Krieg,etal.;Eur.HeartJ.30,1607(2009)
- Cinaciguat(BAY58-2667)improvescardiopulmonaryhemodynamicsinpatientswithacutedecompensatedheartfailure:H.Lapp,etal.;Circulation119,2781(2009)
- Roleofguanylatecyclasemodulatorsindecompensatedheartfailure:V.Mitrovic,etal.;HeartFail.Rev.14,309(2009)(Review)
- Cinaciguat,asolubleguanylatecyclaseactivatorforthepotentialtreatmentofacuteheartfailure:J.Tamargo,etal.;Curr.Opin.Investig.Drugs11,1039(2010)
- Anti-aggregatingeffectofBAY58-2667,anactivatorofsolubleguanylylcyclase:S.Roger,etal.;Vascul.Pharmacol.53,281(2010)
- TransgenicmiceforrealtimevisualizationofcGMPinintactadultcardiomyocytes:K.Götz,etal.;Circ.Res.114,1235(2014)
- SolubleGuanylateCyclaseasaNovelTreatmentTargetforOsteoporosis:J.Joshua,etal.,Endocrinology155,4720(2014)
- ActivationofsolubleguanylylcyclasebyBAY58-2667improvesbladderfunctionincyclophosphamide-inducedcystitisinmice:M.G.deOliveira,etal.;Am.J.Physiol.RenalPhysiol.311,F85(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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