Adipogen/BAY 11-7082/AG-CR1-0013-M010/10 mg
商品编号：
AG-CR1-0013-M010
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile |
| ProductType | Chemical |
| Properties | |
| Formula | C10H9NO2S |
| MW | 207.3 |
| CAS | 19542-67-7 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Whitetooff-whitecrystallinesolid. |
| Solubility | SolubleinDMSO,100%ethanol,dichloromethaneorethylacetate;insolubleinwater. |
| InChiKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- IκBαkinaseinhibitor[1].
- NF-κBinhibitor[1].
- Potentialanti-inflammatoryagent[1].
- Apoptosisinducer[2].
- Inhibitsthereleaseofproinflammatorycytokines[3].
- NLRP3inflammasomeinhibitor[4].ReducesATPaseactivityoftheNLRP3inflammasome.
- Inhibitsplateletaggregation[5].
ProductReferences
- Novelinhibitorofcytokine-inducedIkBaphosphorylationandendothelialcelladhesionmoleculeexpressionshowanti-inflammatoryeffectsinvivo:J.W.Pierce,etal.;J.Biol.Chem.272,21096(1997)
- Bay11-7082inhibitstranscriptionfactorNF-kappaBandinducesapoptosisofHTLV-I-infectedT-celllinesandprimaryadultT-cellleukemiacells:N.Mori,etal.;Blood100,1828(2002)
- SulfasalazineandBAY11-7082interferewiththenuclearfactor-kappaBandIkappaBkinasepathwaytoregulatethereleaseofproinflammatorycytokinesfromhumanADIposetissueandskeletalmuscleinvitro:M.Lappasetal.;Endocrinology146,1491(2005)
- Anti-inflammatorycompoundsparthenolideandBay11-7082aredirectinhibitorsoftheinflammasome:C.Juliana,etal.;J.Biol.Chem.285,9792(2010)
- AnoblefunctionofBAY11-7082:InhibitionofplateletaggregationmediatedbyanelevatedcAMP-inducedVASP,anddecreasedERK2/JNK1phosphorylations:H.S.Lee,etal.;Eur.J.Pharmacol.627,85(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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