Adipogen/Bafilomycin B<sub>1</sub>/BVT-0004-M005/5 mg
商品编号：
BVT-0004-M005
品牌：
Adipogen Inc
市场价：
¥6800.00
美元价：
4080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Setamycin; BRN4640118 |
| Product Type | Chemical |
| Properties | |
| Formula | C44H65NO13 |
| MW | 815.9 |
| CAS | 88899-56-3 |
| RTECS | LX8920000 |
| Source/Host Chemicals | Isolated from Streptomyces hygroscopicus. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO or acetone. Insoluble in water. Unstable in methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | KFUFLYSBMNNJTF-APLCIVFZSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Macrolide antibiotic.
- Specific vacuolar-type H+-ATPase inhibitor.
- Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
- Antitrypanosomal and antileishmanial compound.
- Phytotoxic.
- Influences the cell wall biosynthesis of Asp. niger.
Product References
- Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984)
- Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993)
- Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Drose and K. Altendorf; J. Exp. Biol. 200, 1 (1997)
- Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A: T. Schuhmann and S. Grond; J. Antibiot. (Tokyo) 57, 655 (2004)
- Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006)
- Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy: G. Carr, et al.; Journal of Nat. Prod. 73, 422 (2010)
- Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V. N. Pivtoraiko; J. Neurochem. 114, 1193 (2010)
- Vacuolar H(+)-ATPase plays a keyrole in cell wall biosynthesis of Aspergillus niger: D. Schachtschabel, et al.; Fungalgenet. Biol. 49, 284 (2012)
- Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii: W. Zhang, et al.; ChemBioChem 14, 301 (2013)
- Isolation and characterization of phytotoxic compounds produced by Streptomyces sp. AMC 23 from red mangrove(rhizophora mangle): E. Crevelin, et al.; Appl. Biochem. Biotechnol. 171, 1602 (2013)
- High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and chagas disease: F. Annang, et al.; J. Biomol. Screen. 20, 82 (2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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