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Adipogen/Bafilomycin A<sub>1</sub> (high purity)/BVT-0252-M001/1 mg
Adipogen/Bafilomycin A<sub>1</sub> (high purity)/BVT-0252-M001/1 mg
商品编号：
BVT-0252-M001
品牌：
Adipogen Inc
市场价：
¥3200.00
美元价：
1920.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC381866 |
| ProductType | Chemical |
| Properties | |
| Formula | C35H58O9 |
| MW | 622.8 |
| CAS | 88899-55-2 |
| Source/HostChemicals | IsolatedfromStreptomycesgriseus. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,100%ethanolormethanol. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | XDHNQDDQEHDUTM-AZJYDCQCSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Macrolideantibiotic.
- Specificvacuolar-typeH+-ATPaseinhibitor.
- DistinguishesamongdifferenttypesofATPases.
- Inhibitorofendosomal,lysosomalandvacuolaracidification.
- PreventslysosomalCa2+uptake.
- InhibitorofautophagicdegradationbyrisingpHandthus inactivatingthelysosomalacidhydrolases.
- Neuroprotective.
ProductReferences
- Metabolicproductsofmicroorganisms.224.Bafilomycins,anewgroupofmacrolideantibiotics.Production,isolation,chemicalstructureandBIOLOGicalactivity:G.Werner,etal.;J.Antibiot.37,110(1984)
- Bafilomycins:aclassofinhibitorsofmembraneATPasesfrommicroorganisms,animalcells,andplantcells:E.J.Bowman,etal.;PNAS85,7972(1988)
- InhibitionofosteoclastprotontransportbybafilomycinA1abolishesboneresorption:K.Sundqui,etal.;BBRC168,309(1990)
- KineticstudiesofchromaffingranuleH+-ATPaseandeffectsofbafilomycinA1:H.Hanada,etal.;BBRC170,873(1990)
- BafilomycinA1inhibitsthetargetingoflysosomalacidhydrolasesinculturedhepatocytes:K.Oda,etal.;BBRC178,369(1991)
- BafilomycinA1,aspecificinhibitorofvacuolar-typeH(+)-ATPase,inhibitsacidificationandproteindegradationinlysosomesofculturedcells:T.Yoshimori,etal.;J.Biol.Chem.266,17707(1991)
- BafilomycinA1,aspecificinhibitorofvacuolar-typeH(+)-ATPase,blockslysosomalcholesteroltraffickinginmacrophages:T.Furuchi,etal.;J.Biol.Chem.268,27345(1993)
- Cell-typeandamyloidprecursorprotein-typespecificinhibitionofAbetareleasebybafilomycinA1,aselectiveinhibitorofvacuolarATPases:J.Knops,etal.;J.Biol.Chem.270,2419(1995)
- Autophagy,bafilomycinandcelldeath:the"a-B-cs"ofplecomacrolide-inducedneuroprotection:J.J.Shacka,etal.;Autophagy2,228(2006),(Review)
- BafilomycinA1-sensitivepathwayisrequiredforthematurationofcysticfibrosistransmembraneconductanceregulator:T.Okiyoneda,etal.;Biochim.Biophys.Acta1763,1017(2006)
- Ectopicvesicularneurotransmitterreleasealongsensoryaxonsmediatesneurovascularcouplingviaglialcalciumsignaling:A.Thyssen,etal.;PNAS107,15258(2010)
- Low-doseBafilomycinattenuatesneuronalcelldeathassociatedwithautophagy-lysosomepathwaydysfunction:V.N.Pivtoraiko,etal.;J.NeuRochem.114,1193(2010)
- Alterationsinosteoclastfunctionandphenotypeinducedbydifferentinhibitorsofboneresorption-implicationsforosteoclastquality:A.V.Neutzsky-Wulff,etal.;BMCMusculoskeletalDisorders11, 109(2010)
- RapidrecyclingofCa2+betweenIP3-sensitivestoresandlysosomes:C.I.LopezSanjurjo,etal.;PLoSOne9,e111275/1(2014)
- BafilomycinA1inhibitsautophagyandinducesapoptosisinMG63osteosarcomacells:Z.Xie,etal.;Mol.Med.Rep.10,1103(2014)
- Comparisonofthechemoimmunotherapeuticeffectofdoxorubicinandbafilomycin-A1inmouseneuroblastomacells:S.Inoue,etal.;GanToKagakuRyoho.Cancer&Chemotherapy41,617(2014)
- SuppressionofinfluenzaAvirusreplicationinhumanlungepithelialcellsbynoncytotoxicconcentrationsBafilomycinA1:B.Y,etal.;Am.J.Physiol.LungCellMol.Physiol.308,L270(2015)
- BafilomycinA1targetsbothautophagyandapoptosispathwaysinpediatricB-cellacutelymphoblasticleukemia:N.Yuan,etal.;Haematologica100,345(2015)
- TheprotectiveeffectofbafilomycinA1againstcobaltnanoparticle-inducedcytotoxityandasepticinflammationinmacrophagesinvitro:S.Wang,etal.;Biol.TraceElem.Res.(2015)
- SuppressionofinfluenzaAvirusreplicationinhumanlungepithelialcellsbynoncytotoxicconcentrationsBafilomycinA1:B.Yeganeh,etal.;Am.J.Physiol.308,L270(2015)
- Age-dependentchangesinsynapticplasticityenhancetauoligomerizationinthemousehippocampus:T.Kimura,etal.;ActaNeuropathol.Comm.5,67(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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