![Adipogen/b-AP15 [DUB Inhibitor] Solution/AG-CS1-0102-M010/10 mg](https://www.ebiomall.cn/images/adipogen/ag-cs1-0102_b-ap15_solution.png)
Adipogen/b-AP15 [DUB Inhibitor] Solution/AG-CS1-0102-M010/10 mg
商品编号：
AG-CS1-0102-M010
品牌：
Adipogen Inc
市场价：
¥12180.00
美元价：
7308.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | VLX1500; NSC 687852 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H17N3O6 |
| MW | 419.4 |
| CAS | 1009817-63-3 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Liquid. |
| Formulation | 10mM stock solution in DMSO. |
| Biological Activity | Inhibits purified 19S deubiquitinase activity using Ub-AMC as substrate (in vitro IC50=2.1μM). Decreases HCT-116 cell viability at 72 hours (EC50=0.4μM). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Boston Biochem |
| Other Product Data | Note: May hydrolyze slowly in aqueous buffers. |
| InChi Key | GFARQYQBWJLZMW-JYFOCSDGSA-N |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent, reversible and cell-permeable inhibitor of the 19S deubiquitinases (DUBs) ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5).
- Inhibitor of the 20S proteasome.
- Anti-tumor compound.
Product References
- Inhibition of proteasome deubiquitinating activity as a new cancer therapy: P. D'Arcy, et al.; Nat. Med. 17, 1636 (2011)
- A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance: Z. Tian, et al.; Blood 123, 706 (2014)
- The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death: X. Wang, et al.; Mol. Pharmacol. 85, 932 (2014)
- Inhibitory effect of b-AP15 on the 20S proteasome: L. Huang, et al.; Biomolecules 4, 931 (2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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