Adipogen/AZD1208/SYN-1214-M050/50 mg
商品编号：
SYN-1214-M050
品牌：
Adipogen Inc
市场价：
¥7560.00
美元价：
4536.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | AZD-1208 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H21N3O2S |
| MW | 379.5 |
| CAS | 1204144-28-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Pim-1 / Pim-2 / Pim-3 | Kinase Group: CAMK | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MCUJKPPARUPFJM-UWCCDQBKSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <5nm or=""><150 nm="" in="" enzyme="" and="" cell="" assays,="" respectively.="" potently="" inhibits="" colony="" growth="" and="" pim="" signalling="" substrates="" in="" primary="" aml="" cells="" from="" bone="" marrow="" that="" are="" flt3="" wild-type="" or="" flt3="" internal="" tandem="" duplication="" mutants.="" upregulation="" of="" pim="" kinases="" is="" observed="" in="" several="" types="" of="" leukemias="" and="" lymphomas.="" pim-1,="" -2="" and="" -3="" promote="" cell="" proliferation="" and="" survival="" downstream="" of="" cytokine="" and="" growth="" factor="" signaling="">
Product References
- Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases: L.A. Dakin, et al.; Bioorg. Med. Chem. Lett. 22, 4599 (2012)
- AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia: E.K. Keeton, et al.; Blood 123, 905 (2014)
- The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling: B. Cen, et al.; Mol. Cell Biol. 34, 2517 (2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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