脂肪原/AZD1208/SYN-1214-M010/10毫克
商品编号：
SYN-1214-M010
品牌：
Adipogen Inc
市场价：
¥2160.00
美元价：
1296.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AZD-1208 |
| ProductType | Chemical |
| Properties | |
| Formula | C21H21N3O2S |
| MW | 379.5 |
| CAS | 1204144-28-4 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:Pim-1/Pim-2/Pim-3|KinaseGroup:CAMK|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | MCUJKPPARUPFJM-UWCCDQBKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Potent,highlyselectiveandorallyavailablePimkinaseinhibitorthateffectivelyinhibitsallthreeisoformsPim-1,Pim-2andPim-3at<5nm or=""><150 nm="" in="" enzyme="" and="" cell="" assays,="" respectively.="" potently="" inhibits="" colony="" growth="" and="" pim="" signalling="" substrates="" in="" primary="" aml="" cells="" from="" bone="" marrow="" that="" are="" flt3="" wild-type="" or="" flt3="" internal="" tandem="" duplication="" mutants.="" upregulation="" of="" pim="" kinases="" is="" observed="" in="" several="" types="" of="" leukemias="" and="" lymphomas.="" pim-1,="" -2="" and="" -3="" promote="" cell="" proliferation="" and="" survival="" downstream="" of="" cytokine="" and="" growth="" factor="" signaling="">
ProductReferences
- Discoveryofnovelbenzylidene-1,3-thiazolidine-2,4-dionesaspotentandselectiveinhibitorsofthePIM-1,PIM-2,andPIM-3proteinkinases:L.A.Dakin,etal.;Bioorg.Med.Chem.Lett.22,4599(2012)
- AZD1208,apotentandselectivepan-Pimkinaseinhibitor,demonstratesefficacyinpreclinicalmodelsofacutemyeloidleukemia:E.K.Keeton,etal.;Blood123,905(2014)
- ThePim-1proteinkinaseisanimportantregulatorofMETreceptortyrosinekinaselevelsandsignaling:B.Cen,etal.;Mol.CellBiol.34,2517(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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