Adipogen/AZD-7762 hydrochloride/SYN-1017-M010/10 mg
商品编号：
SYN-1017-M010
品牌：
Adipogen Inc
市场价：
¥3460.00
美元价：
2076.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AZD7762 |
| ProductType | Chemical |
| Properties | |
| Formula | C17H19FN4O2S.HCl |
| MW | 362.4.36.5 |
| CAS | 1246094-78-9 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:Chk1|KinaseGroup:CAMK|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | WFZBLOIXZRZEDG-YDALLXLXSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
CheckpointkinasesCHK1andCHK2areactivatedinresponsetoDNAdamagethatresultsincellcyclearrest,allowingsufficienttimeforDNArepair.Agentsthatleadtoabrogationofsuchcheckpointshavepotentialtoincreasetheefficacyofsuchcompoundsaschemo-andrADIotherapies.AZD7762isaspecificinhibitorfortheCHK1/2kinaseswithIC(50)valueslessthan10.AZD7762enhancesradiationsensitivityandgemcitabine-mediatedradiosensitizationinpancreaticcancercellsandxenograftsandthusishelpfulinthetreatmentsofpotentiallymanycancers.Inaddition,AZD7762isachemosensitizerandwithgemcitabineandradiationproducedasignificantdelayinthegrowthofpancreatictumorxenograftswithtolerabletoxicity.AZD7762isbeingstudiedasanimportantlinkinimprovingbothadjuvanttherapyandthetreatmentofmetastaticdisease.
ProductReferences
- MechanismofradiosensitizationbytheChk1/2inhibitorAZD7762involvesabrogationoftheG2checkpointandinhibitionofhomologousrecombinationalDNArepair:M.A.Morgan,etal.;CancerRes.70,4972(2010)
- Discoveryofcheckpointkinaseinhibitor(S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide(AZD7762)bystructure-baseddesignandoptimizationofthiophenecarboxamideureas:V.Oza,etal.;J.Med.Chem.55,5130(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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